Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D02ONT
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| Former ID |
DIB006959
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| Drug Name |
5-FP
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| Synonyms |
5-Fluoro-2(1H)-pyrimidinone
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| Drug Type |
Small molecular drug
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| Indication | Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C00-D48; ICD-9: 140-199, 210-229] | Phase 1 | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C4H3FN2O
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| Canonical SMILES |
C1=C(C=NC(=O)N1)F
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| InChI |
1S/C4H3FN2O/c5-3-1-6-4(8)7-2-3/h1-2H,(H,6,7,8)
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| InChIKey |
HPABFFGQPLJKBP-UHFFFAOYSA-N
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| CAS Number |
CAS 2022-78-8
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| PubChem Compound ID | ||||
| PubChem Substance ID |
482895, 6246252, 10232087, 10512737, 15264757, 24884205, 26719753, 44431519, 46386867, 49681779, 52731551, 57337398, 60195718, 83104092, 91701277, 91849547, 92308424, 103145095, 104364453, 117506129, 124659022, 125520233, 126639749, 128003296, 128092552, 132629832, 135057887, 140349084, 143068206, 160827434, 162022178, 162237190, 163093211, 163391864, 163843338, 164202019, 164784370, 172080408, 179295976, 198985851, 204385775, 223578610, 223843422, 226648477, 241038813, 241052539, 242074146, 249774070, 249782080, 249826755
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| ChEBI ID |
CHEBI:125539
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Human Deoxyribonucleic acid (hDNA) | Target Info | Binder | [2] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Antitumor properties of 2(1H)-pyrimidinone riboside (zebularine) and its fluorinated analogues. J Med Chem. 1991 Nov;34(11):3280-4. | |||
| REF 2 | Is the measurement of thymidylate synthase to determine suitability for treatment with 5-fluoropyrimidines ready for prime time. Clin Cancer Res. 2003 Apr;9(4):1235-9. | |||
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