Drug Information
Drug General Information | Top | |||
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Drug ID |
D02RUO
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Former ID |
DIB000070
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Drug Name |
ONO-8815Ly
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Synonyms |
ONO-8815Lyn; ONO-AE-1259
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Drug Type |
Small molecular drug
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Indication | Miscarriage [ICD-11: JA00.0] | Terminated | [1], [2] | |
Company |
Ono Pharmaceutical Co Ltd
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Structure |
Download2D MOL |
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Formula |
C22H35ClO4
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Canonical SMILES |
CCC1(CCC1)C(CC=CC2C(CC(C2CC=CCCCC(=O)O)Cl)O)O
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InChI |
1S/C22H35ClO4/c1-2-22(13-8-14-22)20(25)11-7-10-17-16(18(23)15-19(17)24)9-5-3-4-6-12-21(26)27/h3,5,7,10,16-20,24-25H,2,4,6,8-9,11-15H2,1H3,(H,26,27)/b5-3-,10-7+/t16-,17-,18-,19-,20+/m1/s1
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InChIKey |
LBIPUBVVGYRBNA-VGUVCEGPSA-N
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PubChem Compound ID | ||||
PubChem Substance ID |
Target and Pathway | Top | |||
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Target(s) | Prostaglandin E2 receptor EP2 (PTGER2) | Target Info | Agonist | [3] |
KEGG Pathway | cAMP signaling pathway | |||
Neuroactive ligand-receptor interaction | ||||
Inflammatory mediator regulation of TRP channels | ||||
Renin secretion | ||||
Pathways in cancer | ||||
Reactome | Prostanoid ligand receptors | |||
G alpha (s) signalling events | ||||
WikiPathways | Prostaglandin Synthesis and Regulation | |||
GPCRs, Class A Rhodopsin-like | ||||
Ovarian Infertility Genes | ||||
Small Ligand GPCRs | ||||
GPCR ligand binding | ||||
GPCR downstream signaling |
References | Top | |||
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REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1932). | |||
REF 2 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800012532) | |||
REF 3 | Prostaglandin E2 receptor type 2-selective agonist prevents the degeneration of articular cartilage in rabbit knees with traumatic instability. Arthritis Res Ther. 2011;13(5):R146. |
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