Drug Information
Drug General Information | Top | |||
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Drug ID |
D02UIE
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Former ID |
DIB003253
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Drug Name |
ZK-91296
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Synonyms |
ZK 91296; 83910-34-3; Ethyl 5-benzyloxy-4-methoxymethyl-beta-carboline-3-carboxylate; 9H-Pyrido(3,4-b)indole-3-carboxylic acid, 4-(methoxymethyl)-5-(phenylmethoxy)-, ethyl ester; WFPXOWCKXUEKCA-UHFFFAOYSA-N; AC1Q64YJ; SCHEMBL8845201; AC1L3X51; zk91296; BDBM85040; PDSP2_001753; ethyl 5-(benzyloxy)-4-(methoxymethyl)-9h-; PDSP1_001770; CAS_123700; NSC_123700; LS-187464; LS-186794; 5-benzyloxy-4-methoxymethyl-beta-carboline-3-carboxylic acid-ethyl ester
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Drug Type |
Small molecular drug
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Indication | Alzheimer disease [ICD-11: 8A20; ICD-10: G30, G30.9; ICD-9: 331] | Terminated | [1] | |
Company |
Bayer Schering Pharma AG
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Structure |
Download2D MOL |
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Formula |
C23H22N2O4
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Canonical SMILES |
CCOC(=O)C1=NC=C2C(=C1COC)C3=C(N2)C=CC=C3OCC4=CC=CC=C4
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InChI |
1S/C23H22N2O4/c1-3-28-23(26)22-16(14-27-2)20-18(12-24-22)25-17-10-7-11-19(21(17)20)29-13-15-8-5-4-6-9-15/h4-12,25H,3,13-14H2,1-2H3
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InChIKey |
WFPXOWCKXUEKCA-UHFFFAOYSA-N
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CAS Number |
CAS 83910-34-3
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | GABA(A) receptor gamma-3 (GABRG3) | Target Info | Modulator | [2] |
KEGG Pathway | Neuroactive ligand-receptor interaction | |||
Retrograde endocannabinoid signaling | ||||
GABAergic synapse | ||||
Morphine addiction | ||||
Nicotine addiction | ||||
Reactome | Ligand-gated ion channel transport | |||
GABA A receptor activation | ||||
WikiPathways | SIDS Susceptibility Pathways | |||
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | ||||
Iron uptake and transport |
References | Top | |||
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REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000552) | |||
REF 2 | Enhancement of gamma-aminobutyric acid binding by the anxiolytic beta-carbolines ZK 93423 and ZK 91296. J Neurochem. 1987 May;48(5):1355-8. |
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