Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D02XSA
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| Former ID |
DIB013227
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| Drug Name |
Stiripentol
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| Synonyms |
Diacomit; ME-2080; Stiripentol (oral); Stiripentol (oral), Laboratoires Biocodex
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| Drug Type |
Small molecular drug
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| Indication | Dravet syndrome [ICD-11: 8A61.11] | Approved | [1] | |
| Epilepsy [ICD-11: 8A60-8A68] | Approved | [2], [3] | ||
| Company |
Biocodex
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| Structure |
 |
Download2D MOL |
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| Formula |
C14H18O3
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| Canonical SMILES |
CC(C)(C)C(C=CC1=CC2=C(C=C1)OCO2)O
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| InChI |
1S/C14H18O3/c1-14(2,3)13(15)7-5-10-4-6-11-12(8-10)17-9-16-11/h4-8,13,15H,9H2,1-3H3/b7-5+
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| InChIKey |
IBLNKMRFIPWSOY-FNORWQNLSA-N
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| CAS Number |
CAS 49763-96-4
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| PubChem Compound ID | ||||
| PubChem Substance ID |
7980667, 11056518, 12012842, 14822996, 26719721, 39341128, 46386912, 47207586, 49681794, 50003116, 50296460, 53787806, 57359489, 92308635, 114156142, 124659075, 124800322, 124896656, 126687172, 135001137, 137249320, 140896155, 144207171, 160682657, 162248724, 164814427, 172080465, 178102119, 179150500, 179295999, 184546144, 223434582, 223671334, 224537897, 226570508, 228636166, 250056868, 251916521, 251917868, 252356786, 252671637
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| ChEBI ID |
CHEBI:94435
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| ADReCS Drug ID | BADD_D02069 | |||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | GABA(A) receptor gamma-3 (GABRG3) | Target Info | Modulator | [3], [4] |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Retrograde endocannabinoid signaling | ||||
| GABAergic synapse | ||||
| Morphine addiction | ||||
| Nicotine addiction | ||||
| Reactome | Ligand-gated ion channel transport | |||
| GABA A receptor activation | ||||
| WikiPathways | SIDS Susceptibility Pathways | |||
| Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | ||||
| Iron uptake and transport | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | The effects of stiripentol on GABA(A) receptors.Epilepsia. 2011 Apr;52 Suppl 2:76-8. | |||
| REF 2 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5469). | |||
| REF 3 | Stiripentol, a putative antiepileptic drug, enhances the duration of opening of GABA-A receptor channels. Epilepsia. 2006 Apr;47(4):704-16. | |||
| REF 4 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
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