Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D02YSI
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| Former ID |
DNC008061
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| Drug Name |
FR-901277
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| Synonyms |
CHEMBL437538; FR-901277; BDBM50080264
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| Drug Type |
Small molecular drug
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| Structure |
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Download2D MOL |
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| Formula |
C47H63N9O13
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| Canonical SMILES |
CC=C1C(=O)NC2CCC(N(C2=O)C(C(=O)N(C3CC4=CC(=C(C=C4NC(=O)NCCCC(C(=O)NC(C(OC(=O)C(NC3=O)C(C)C)C)C(=O)N1)NC(=O)C(C)C)O)O)C)CC5=CC=CC=C5)O
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| InChI |
1S/C47H63N9O13/c1-8-28-40(61)51-30-16-17-36(59)56(44(30)65)33(19-26-13-10-9-11-14-26)45(66)55(7)32-20-27-21-34(57)35(58)22-31(27)52-47(68)48-18-12-15-29(50-39(60)24(4)5)41(62)54-38(43(64)49-28)25(6)69-46(67)37(23(2)3)53-42(32)63/h8-11,13-14,21-25,29-30,32-33,36-38,57-59H,12,15-20H2,1-7H3,(H,49,64)(H,50,60)(H,51,61)(H,53,63)(H,54,62)(H2,48,52,68)/b28-8-/t25-,29-,30-,32-,33-,36+,37-,38-/m0/s1
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| InChIKey |
MHMMGTGXNPFNAJ-MVPXUFHVSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Neutrophil elastase (NE) | Target Info | Inhibitor | [1] |
| KEGG Pathway | Transcriptional misregulation in cancer | |||
| Systemic lupus erythematosus | ||||
| Pathway Interaction Database | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling | |||
| C-MYB transcription factor network | ||||
| Reactome | Collagen degradation | |||
| Degradation of the extracellular matrix | ||||
| Activation of Matrix Metalloproteinases | ||||
| WikiPathways | Hair Follicle Development: Cytodifferentiation (Part 3 of 3) | |||
| Human Complement System | ||||
| Degradation of collagen | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Resisting degradation by human elastase: commonality of design features shared by 'canonical' plant and bacterial macrocyclic protease inhibitor sc... Bioorg Med Chem. 2007 Jul 1;15(13):4618-28. | |||
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