Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D02ZPZ
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| Former ID |
DNC003712
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| Drug Name |
5-((E)-Styryl)-quinazoline-2,4-diamine
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| Synonyms |
CHEMBL164845; 5-((E)-Styryl)-quinazoline-2,4-diamine; AC1O6QWN; ZINC5974460; BDBM50036484
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C16H14N4
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| Canonical SMILES |
C1=CC=C(C=C1)C=CC2=C3C(=CC=C2)N=C(N=C3N)N
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| InChI |
1S/C16H14N4/c17-15-14-12(10-9-11-5-2-1-3-6-11)7-4-8-13(14)19-16(18)20-15/h1-10H,(H4,17,18,19,20)/b10-9+
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| InChIKey |
YPIDSPOROIRHIL-MDZDMXLPSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Polypeptide deformylase (PDF) | Target Info | Inhibitor | [1] |
| Pathwhiz Pathway | Folate Metabolism | |||
| Pterine Biosynthesis | ||||
| Reactome | E2F mediated regulation of DNA replication | |||
| Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | ||||
| Metabolism of folate and pterines | ||||
| G1/S-Specific Transcription | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | 2,4-Diamino-5-substituted-quinazolines as inhibitors of a human dihydrofolate reductase with a site-directed mutation at position 22 and of the dih... J Med Chem. 1995 Mar 3;38(5):745-52. | |||
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