Drug Information

Drug General Information

Drug ID

D03EOZ

Drug Name

IMG-7289

Synonyms

KQKBMHGOHXOHTD-KKUQBAQOSA-N; UNII-Y2T4ALDEAT; Y2T4ALDEAT; SCHEMBL17984236; Benzamide, N-((1S)-4-(((1R,2S)-2-(4-fluorophenyl)cyclopropyl)amino)-1-((4-methyl-1-piperazinyl)carbonyl)butyl)-4-(1H-1,2,3-triazol-1-yl)-; 1990504-34-1; N-[(2S)-1-(4-(methyl)piperazin-1-yl)-5-[[(1R,2S)-2-(4-fluorophenyl)-cyclopropyl]amino]-1-oxopentan-2-yl]-4-(1H-1,2,3-triazol-1-yl)benzamide

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Indication

Acute myeloid leukaemia [ICD-11: 2A60]

Phase 2

[1]

Myelodysplastic syndrome [ICD-11: 2A37; ICD-9: 238.7]

Phase 2

[1]

Myelofibrosis [ICD-11: 2A20.2; ICD-10: D47.4]

Phase 1/2

[1]

Company

Imago BioSciences San Carlos, CA

Structure

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2D MOL

3D MOL

Formula

C28H34FN7O2

Canonical SMILES

CN1CCN(CC1)C(=O)C(CCCNC2CC2C3=CC=C(C=C3)F)NC(=O)C4=CC=C(C=C4)N5C=CN=N5

InChI

1S/C28H34FN7O2/c1-34-15-17-35(18-16-34)28(38)25(3-2-12-30-26-19-24(26)20-4-8-22(29)9-5-20)32-27(37)21-6-10-23(11-7-21)36-14-13-31-33-36/h4-11,13-14,24-26,30H,2-3,12,15-19H2,1H3,(H,32,37)/t24-,25-,26+/m0/s1

InChIKey

KQKBMHGOHXOHTD-KKUQBAQOSA-N

CAS Number

CAS 1990504-34-1

PubChem Compound ID

122460381

Target and Pathway

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Target(s)

Lysine-specific histone demethylase 1 (LSD)

Target Info

Inhibitor