Drug Information
Drug General Information | Top | |||
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Drug ID |
D03GGN
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Former ID |
DIB002438
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Drug Name |
RO-09-4889
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Synonyms |
Ro-0094889; 2',3'-Di-O-acetyl-5'-deoxy-5-vinylcytidine
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Indication | Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C76-C80; ICD-9: 140-229] | Phase 1 | [1] | |
Structure |
Download2D MOL |
Target and Pathway | Top | |||
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Target(s) | Dihydrothymine dehydrogenase (DPYD) | Target Info | Modulator | [1], [2] |
BioCyc | Pyrimidine ribonucleosides degradation | |||
Thymine degradation | ||||
Uracil degradation | ||||
KEGG Pathway | Pyrimidine metabolism | |||
beta-Alanine metabolism | ||||
Pantothenate and CoA biosynthesis | ||||
Drug metabolism - other enzymes | ||||
Metabolic pathways | ||||
Panther Pathway | Pyrimidine Metabolism | |||
Pathwhiz Pathway | Beta-Alanine Metabolism | |||
Pyrimidine Metabolism | ||||
WikiPathways | Metabolism of nucleotides | |||
Fluoropyrimidine Activity |
References | Top | |||
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REF 1 | Single ascending dose tolerability, pharmacokinetic-pharmacodynamic study of dihydropyrimidine dehydrogenase inhibitor Ro 09-4889. Clin Cancer Res. 2004 Apr 1;10(7):2327-35. | |||
REF 2 | Therapeutic target database update 2012: a resource for facilitating target-oriented drug discovery. Nucleic Acids Res. 2012 Jan;40(Database issue):D1128-36. |
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