Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D03ICO
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| Former ID |
DIB010092
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| Drug Name |
AR-709
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| Synonyms |
AR-103; AR-103 program, Arpida
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| Drug Type |
Small molecular drug
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| Indication | Bacterial infection [ICD-11: 1A00-1C4Z; ICD-10: A00-B99] | Terminated | [1] | |
| Company |
Evolva Holding SA
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| Structure |
 |
Download2D MOL |
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| Formula |
C27H27ClN6O4
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| Canonical SMILES |
CN(C)C(=O)C1=C(C2=C(N1)C=CC(=C2)Cl)CC3=CC4=C(O3)C(=C(C=C4CC5=CN=C(N=C5N)N)OC)OC
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| InChI |
1S/C27H27ClN6O4/c1-34(2)26(35)22-19(18-9-15(28)5-6-20(18)32-22)11-16-10-17-13(7-14-12-31-27(30)33-25(14)29)8-21(36-3)24(37-4)23(17)38-16/h5-6,8-10,12,32H,7,11H2,1-4H3,(H4,29,30,31,33)
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| InChIKey |
ASSNCSVJAZEMQG-UHFFFAOYSA-N
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| CAS Number |
CAS 663214-64-0
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Bacterial Dihydrofolate reductase (Bact DHFR) | Target Info | Modulator | [2], [2] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800020451) | |||
| REF 2 | Activity of the Diaminopyrimidine AR-709 against Recently Collected Multidrug-Resistant Isolates of Invasive Streptococcus pneumoniae from North America | |||
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