Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D03LMM
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| Former ID |
DNC002643
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| Drug Name |
G418
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| Synonyms |
Geneticin; geneticin; antibiotic G 418; antibiotic G-418; UNII-A08F5XTI6G; 49863-47-0; BRN 1669188; A08F5XTI6G; O-2-Amino-2,7-dideoxy-D-glycero-alpha-D-gluco-heptopyranosyl-(1-4)-O-(3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranosyl-(1-6))-D-streptamine; G 418 sulfate; G 418; G-418; C20H40N4O10; GET; D-Streptamine, O-2-amino-2,7-dideoxy-D-glycero-alpha-D-gluco-heptopyranosyl-(1-4)-O-(3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranosyl-(1-6))-; AC1L3XFV; SCHEMBL5006573; CHEMBL215226; DTXSID10198129
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1], [2] | |
| Structure |
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Download2D MOL |
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| Formula |
C20H40N4O10
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| Canonical SMILES |
CC(C1C(C(C(C(O1)OC2C(CC(C(C2O)OC3C(C(C(CO3)(C)O)NC)O)N)N)N)O)O)O
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| InChI |
1S/C20H40N4O10/c1-6(25)14-11(27)10(26)9(23)18(32-14)33-15-7(21)4-8(22)16(12(15)28)34-19-13(29)17(24-3)20(2,30)5-31-19/h6-19,24-30H,4-5,21-23H2,1-3H3/t6-,7+,8-,9-,10-,11+,12+,13-,14-,15-,16+,17-,18-,19-,20+/m1/s1
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| InChIKey |
BRZYSWJRSDMWLG-DJWUNRQOSA-N
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| CAS Number |
CAS 49863-47-0
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| PubChem Compound ID | ||||
| PubChem Substance ID |
651382, 7887824, 26708770, 29304044, 50047889, 51060325, 57340625, 85286096, 96024033, 103072798, 103078072, 103499571, 104419512, 127324866, 127324867, 127324868, 127324869, 127324870, 127324871, 127324872, 127324873, 127324874, 131271576, 135080171, 139650597, 163716078, 184548255, 198948062, 223873142, 230880711, 243275896, 252300370
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Bacterial 16S ribosomal RNA (Bact 16S rRNA) | Target Info | Inhibitor | [2] |
| Ornithine decarboxylase (ODC1) | Target Info | Inhibitor | [1] | |
| BioCyc | Putrescine biosynthesis I | |||
| NetPath Pathway | TCR Signaling Pathway | |||
| IL2 Signaling Pathway | ||||
| TGF_beta_Receptor Signaling Pathway | ||||
| Panther Pathway | Ornithine degradation | |||
| CCKR signaling map ST | ||||
| Pathwhiz Pathway | Spermidine and Spermine Biosynthesis | |||
| Pathway Interaction Database | Validated targets of C-MYC transcriptional activation | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. | |||
| REF 2 | RNA as a target for small molecules. Curr Opin Chem Biol. 2000 Dec;4(6):678-86. | |||
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