Drug Information
Drug General Information | Top | |||
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Drug ID |
D03MQA
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Former ID |
DNC008766
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Drug Name |
4-(cyclopropylmethylthio)-2-methoxybenzonitrile
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Synonyms |
CHEMBL504110; 4-(cyclopropylmethylthio)-2-methoxybenzonitrile
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL |
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Formula |
C12H13NOS
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Canonical SMILES |
COC1=C(C=CC(=C1)SCC2CC2)C#N
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InChI |
1S/C12H13NOS/c1-14-12-6-11(5-4-10(12)7-13)15-8-9-2-3-9/h4-6,9H,2-3,8H2,1H3
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InChIKey |
KLTYCOFPIFASIE-UHFFFAOYSA-N
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Androgen receptor messenger RNA (AR mRNA) | Target Info | Inhibitor | [1] |
KEGG Pathway | Oocyte meiosis | |||
Pathways in cancer | ||||
Prostate cancer | ||||
NetPath Pathway | EGFR1 Signaling Pathway | |||
AndrogenReceptor Signaling Pathway | ||||
FSH Signaling Pathway | ||||
Pathway Interaction Database | Regulation of nuclear SMAD2/3 signaling | |||
Coregulation of Androgen receptor activity | ||||
Regulation of Androgen receptor activity | ||||
Nongenotropic Androgen signaling | ||||
Regulation of nuclear beta catenin signaling and target gene transcription | ||||
FOXA1 transcription factor network | ||||
Notch-mediated HES/HEY network | ||||
Reactome | Nuclear Receptor transcription pathway | |||
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 | ||||
WikiPathways | SIDS Susceptibility Pathways | |||
Integrated Pancreatic Cancer Pathway | ||||
Prostate Cancer | ||||
Integrated Breast Cancer Pathway | ||||
Nuclear Receptors | ||||
Androgen receptor signaling pathway |
References | Top | |||
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REF 1 | 4-(Alkylthio)- and 4-(arylthio)-benzonitrile derivatives as androgen receptor antagonists for the topical suppression of sebum production. Bioorg Med Chem Lett. 2009 Mar 1;19(5):1310-3. |
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