Drug Information
Drug General Information | Top | |||
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Drug ID |
D03POU
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Former ID |
DNC003522
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Drug Name |
8-(3,4-dimethoxyphenyl)-9H-purine-2,6-diamine
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Synonyms |
8-(3,4-dimethoxyphenyl)-9H-purine-2,6-diamine; CHEMBL102518; AC1LAR99; CTK7A7284; BDBM50059936; 2,6-Diamino-8-(3',4'-dimethoxyphenyl)purine; 8-(3,4-dimethoxyphenyl)-3h-purine-2,6-diamine; 8-(3,4-dimethoxyphenyl)-7H-purine-2,6-diamine
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL |
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Formula |
C13H14N6O2
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Canonical SMILES |
COC1=C(C=C(C=C1)C2=NC3=NC(=NC(=C3N2)N)N)OC
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InChI |
1S/C13H14N6O2/c1-20-7-4-3-6(5-8(7)21-2)11-16-9-10(14)17-13(15)19-12(9)18-11/h3-5H,1-2H3,(H5,14,15,16,17,18,19)
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InChIKey |
LXQDFGKWPJDZOK-UHFFFAOYSA-N
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Polypeptide deformylase (PDF) | Target Info | Inhibitor | [1] |
Pathwhiz Pathway | Folate Metabolism | |||
Pterine Biosynthesis | ||||
Reactome | E2F mediated regulation of DNA replication | |||
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | ||||
Metabolism of folate and pterines | ||||
G1/S-Specific Transcription |
References | Top | |||
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REF 1 | CoMFA analysis of tgDHFR and rlDHFR based on antifolates with 6-5 fused ring system using the all-orientation search (AOS) routine and a modified c... Bioorg Med Chem. 2010 Feb 15;18(4):1684-701. |
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