Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D03QCW
|
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| Former ID |
DAP001280
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| Drug Name |
Interferon alfa-n1
|
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| Synonyms |
Well-feron; Interferon alfa-n1 (USAN); Well-feron (TN)
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|
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| Indication | Chronic myelogenous leukaemia [ICD-11: 2A20.0; ICD-10: C92.1] | Approved | [1], [2] | |
| Therapeutic Class |
Antiviral Agents
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| PubChem Substance ID | ||||
| SuperDrug ATC ID |
L03AB06
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Interferon alpha/beta receptor 2 (IFNAR2) | Target Info | Binder | [3], [4], [5] |
| KEGG Pathway | Cytokine-cytokine receptor interaction | |||
| PI3K-Akt signaling pathway | ||||
| Osteoclast differentiation | ||||
| Toll-like receptor signaling pathway | ||||
| Jak-STAT signaling pathway | ||||
| Natural killer cell mediated cytotoxicity | ||||
| Hepatitis C | ||||
| Hepatitis B | ||||
| Measles | ||||
| Influenza A | ||||
| Herpes simplex infection | ||||
| Reactome | Interferon alpha/beta signaling | |||
| Regulation of IFNA signaling | ||||
| WikiPathways | Toll-like receptor signaling pathway | |||
| Interferon type I signaling pathways | ||||
| Interferon alpha/beta signaling | ||||
| Regulation of toll-like receptor signaling pathway | ||||
| Osteoclast Signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. | |||
| REF 2 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
| REF 3 | Lymphoblastoid interferon alfa-n1 improves the long-term response to a 6-month course of treatment in chronic hepatitis C compared with recombinant interferon alfa-2b: results of an international randomized controlled trial. Clinical Advisory Group for the Hepatitis C Comparative Study. Hepatology. 1998 Apr;27(4):1121-7. | |||
| REF 4 | Therapy of hepatitis C: interferon alfa-n1 trials. Hepatology. 1997 Sep;26(3 Suppl 1):96S-100S. | |||
| REF 5 | The clinical application of the interferons: a review. NSW Therapeutic Assessment Group. Med J Aust. 1992 Jun 15;156(12):869-72. | |||
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