Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D03UID
|
|||
| Former ID |
DNC001218
|
|||
| Drug Name |
RJR-2403
|
|||
| Synonyms |
Metanicotine; Rivanicline; RJR-2403; Trans-metanicotine; 15585-43-0; Rivanicline [INN]; 538-79-4; (E)-Metanicotine; UNII-6H35LF645A; NSC 66331; 3-Buten-1-amine, N-methyl-4-(3-pyridinyl)-; TC-2403; AI3-18211; CHEMBL132966; 6H35LF645A; (3E)-N-Methyl-4-(pyridin-3-yl)but-3-en-1-amine; But-3-en-1-amine, N-methyl-4-(pyridin-3-yl)-, (E)-; Pyridine, 3-(4-(methylamino)-1-butenyl)-; (E)-N-methyl-4-pyridin-3-ylbut-3-en-1-amine; (3E)-N-methyl-4-(3-pyridinyl)-3-buten-1-amine
Click to Show/Hide
|
|||
| Drug Type |
Small molecular drug
|
|||
| Indication | Cognitive impairment [ICD-11: 6D71; ICD-10: F06.7] | Discontinued in Phase 2 | [1], [2] | |
| Structure |
 |
Download2D MOL |
||
| Formula |
C10H14N2
|
|||
| Canonical SMILES |
CNCCC=CC1=CN=CC=C1
|
|||
| InChI |
1S/C10H14N2/c1-11-7-3-2-5-10-6-4-8-12-9-10/h2,4-6,8-9,11H,3,7H2,1H3/b5-2+
|
|||
| InChIKey |
JUOSGGQXEBBCJB-GORDUTHDSA-N
|
|||
| CAS Number |
CAS 15585-43-0
|
|||
| PubChem Compound ID | ||||
| PubChem Substance ID |
111416, 609860, 7978539, 11056174, 15171050, 26752048, 39340703, 50032750, 50064512, 53091354, 57359305, 103129209, 103369533, 103957123, 114154935, 117521745, 132556611, 134224167, 135029806, 135253531, 136352882, 137001273, 137010080, 143156490, 152258469, 152344535, 160647304, 164229888, 164762647, 164780426, 175427044, 178100820, 198984640, 198992135, 223807308, 226492038, 226492039, 252479545
|
|||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Nicotinic acetylcholine receptor (nAChR) | Target Info | Agonist | [3] |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Reactome | Highly sodium permeable acetylcholine nicotinic receptors | |||
| Highly calcium permeable postsynaptic nicotinic acetylcholine receptors | ||||
| WikiPathways | Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3994). | |||
| REF 2 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800007149) | |||
| REF 3 | The therapeutic potential of nicotinic acetylcholine receptor agonists for pain control. Expert Opin Investig Drugs. 2001 Oct;10(10):1819-30. | |||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.