Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D04AUA
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| Former ID |
DIB001385
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| Drug Name |
MIV-170
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| Synonyms |
MIV-140; MSK-076; Non-nucleoside reverse transcriptase inhibitors, Medivir; HIV polymerase inhibitors, Medivir/Bristol-Myers Squibb; NNRTIs (HIV infection), Medivir/Bristol-Myers Squibb
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| Drug Type |
Small molecular drug
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| Indication | Human immunodeficiency virus infection [ICD-11: 1C62; ICD-9: 279.3] | Terminated | [1] | |
| Company |
Medivir AB
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| Structure |
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Download2D MOL |
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| Formula |
C24H21F2N3O4S
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| Canonical SMILES |
C1CC2=C(C=CC(=C2C3C1C3NC(=O)NC4=CC=C(C=C4)OC5=CC=C(C=C5)S(=O)(=O)N)F)F
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| InChI |
1S/C24H21F2N3O4S/c25-19-11-12-20(26)21-17(19)9-10-18-22(21)23(18)29-24(30)28-13-1-3-14(4-2-13)33-15-5-7-16(8-6-15)34(27,31)32/h1-8,11-12,18,22-23H,9-10H2,(H2,27,31,32)(H2,28,29,30)/t18-,22-,23-/m1/s1
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| InChIKey |
FRIDRXJGZVLPIQ-SXSPYAJSSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Human immunodeficiency virus Reverse transcriptase (HIV RT) | Target Info | Inhibitor | [2] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800019379) | |||
| REF 2 | Inhibition of HIV-1 by non-nucleoside reverse transcriptase inhibitors via an induced fit mechanism-Importance of slow dissociation and relaxation rates for antiviral efficacy. Biochem Pharmacol. 2010 Oct 15;80(8):1133-40. | |||
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