Drug Information
Drug General Information | Top | |||
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Drug ID |
D04FDN
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Former ID |
DNCL002263
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Drug Name |
Palifosfamide
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Synonyms |
ZIO-201
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Drug Type |
Small molecular drug
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Indication | Soft tissue sarcoma [ICD-11: 2B57; ICD-9: 171] | Phase 2 | [1] | |
Company |
ZIOPHARM Oncology
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Structure |
Download2D MOL |
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Formula |
C4H11Cl2N2O2P
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Canonical SMILES |
C(CCl)NP(=O)(NCCCl)O
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InChI |
1S/C4H11Cl2N2O2P/c5-1-3-7-11(9,10)8-4-2-6/h1-4H2,(H3,7,8,9,10)
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InChIKey |
BKCJZNIZRWYHBN-UHFFFAOYSA-N
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CAS Number |
CAS 31645-39-3
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PubChem Compound ID | ||||
PubChem Substance ID | ||||
ChEBI ID |
CHEBI:80566
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Target and Pathway | Top | |||
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Target(s) | DNA [cytosine-5]-methyltransferase 1 (DNMT1) | Target Info | Inhibitor | [2] |
KEGG Pathway | Cysteine and methionine metabolism | |||
Metabolic pathways | ||||
MicroRNAs in cancer | ||||
Pathwhiz Pathway | Methionine Metabolism | |||
Pathway Interaction Database | Regulation of retinoblastoma protein | |||
Reactome | PRC2 methylates histones and DNA | |||
NoRC negatively regulates rRNA expression | ||||
DNA methylation | ||||
WikiPathways | Trans-sulfuration and one carbon metabolism | |||
Retinoblastoma (RB) in Cancer | ||||
One Carbon Metabolism | ||||
Trans-sulfuration pathway |
References | Top | |||
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REF 1 | ClinicalTrials.gov (NCT01808534) Palifosfamide in Treating Patients With Recurrent Germ Cell Tumors. U.S. National Institutes of Health. | |||
REF 2 | Anticancer activity of stabilized palifosfamide in vivo: schedule effects, oral bioavailability, and enhanced activity with docetaxel and doxorubicin. Anticancer Drugs. 2012 Feb;23(2):173-84. |
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