Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D04KZN
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| Former ID |
DIB016560
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| Drug Name |
CTP-354
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| Indication | Pain [ICD-11: MG30-MG3Z] | Discontinued in Phase 1 | [1] | |
| Company |
Concert pharmaceuticals
|
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| Structure |
 |
Download2D MOL |
||
| Formula |
C19H19F2N7O
|
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| Canonical SMILES |
CC(C)(C)C1=CC2=NN=C(N2N=C1OCC3=NC=NN3C)C4=C(C=CC(=C4)F)F
|
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| InChI |
1S/C19H19F2N7O/c1-19(2,3)13-8-15-24-25-17(12-7-11(20)5-6-14(12)21)28(15)26-18(13)29-9-16-22-10-23-27(16)4/h5-8,10H,9H2,1-4H3/i1D3,2D3,3D3
|
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| InChIKey |
BQDUNOMMYOKHEP-GQALSZNTSA-N
|
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | GABA(A) receptor gamma-3 (GABRG3) | Target Info | Modulator | [2] |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Retrograde endocannabinoid signaling | ||||
| GABAergic synapse | ||||
| Morphine addiction | ||||
| Nicotine addiction | ||||
| Reactome | Ligand-gated ion channel transport | |||
| GABA A receptor activation | ||||
| WikiPathways | SIDS Susceptibility Pathways | |||
| Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | ||||
| Iron uptake and transport | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800038187) | |||
| REF 2 | Clinical pipeline report, company report or official report of Concert Pharmaceuticals. | |||
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