Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D04UBQ
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| Former ID |
DNC003517
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| Drug Name |
8-(3,4-dichlorophenyl)-9H-purine-2,6-diamine
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| Synonyms |
8-(3,4-dichlorophenyl)-9H-purine-2,6-diamine; CHEMBL312688; 8-(3,4-dichlorophenyl)-7H-purine-2,6-diamine; AC1LAR9C; CTK7E1080; BDBM50059929; 2,6-Diamino-8-(3',4'-dichlorophenyl)purine
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C11H8Cl2N6
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| Canonical SMILES |
C1=CC(=C(C=C1C2=NC3=NC(=NC(=C3N2)N)N)Cl)Cl
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| InChI |
1S/C11H8Cl2N6/c12-5-2-1-4(3-6(5)13)9-16-7-8(14)17-11(15)19-10(7)18-9/h1-3H,(H5,14,15,16,17,18,19)
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| InChIKey |
GZDRYQKQDXYCQK-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Polypeptide deformylase (PDF) | Target Info | Inhibitor | [1] |
| Pathwhiz Pathway | Folate Metabolism | |||
| Pterine Biosynthesis | ||||
| Reactome | E2F mediated regulation of DNA replication | |||
| Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | ||||
| Metabolism of folate and pterines | ||||
| G1/S-Specific Transcription | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | CoMFA analysis of tgDHFR and rlDHFR based on antifolates with 6-5 fused ring system using the all-orientation search (AOS) routine and a modified c... Bioorg Med Chem. 2010 Feb 15;18(4):1684-701. | |||
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