Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D05GKD
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| Former ID |
DAP000140
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| Drug Name |
Tramadol
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| Synonyms |
Conzip; Ryzolt; Tramadol Hydrochloride; Ultram Er; Rybix Odt; Ultram
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| Drug Type |
Small molecular drug
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| Indication | Pain [ICD-11: MG30-MG3Z] | Approved | [1], [2] | |
| Therapeutic Class |
Analgesics
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| Company |
Chemie Grunenthal of Stolberg-am-Rhein
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| Structure |
 |
Download2D MOL |
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| Formula |
C16H25NO2
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| Canonical SMILES |
CN(C)CC1CCCCC1(C2=CC(=CC=C2)OC)O
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| InChI |
1S/C16H25NO2/c1-17(2)12-14-7-4-5-10-16(14,18)13-8-6-9-15(11-13)19-3/h6,8-9,11,14,18H,4-5,7,10,12H2,1-3H3/t14-,16+/m1/s1
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| InChIKey |
TVYLLZQTGLZFBW-ZBFHGGJFSA-N
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| CAS Number |
CAS 123154-38-1
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| PubChem Compound ID | ||||
| PubChem Substance ID |
5658598, 8153398, 15221636, 29224565, 49958171, 49958172, 49958173, 50837838, 85209685, 103113054, 104309473, 117617520, 123083206, 125679912, 126682485, 129321889, 134995846, 135060961, 137010486, 142192184, 162831124, 164174929, 164765703, 164765706, 179225203, 184526607, 184596120, 216106831, 223656715, 223766038, 226439878, 241058775, 244533735, 249923528, 252166498
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| ChEBI ID |
CHEBI:75725
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| ADReCS Drug ID | BADD_D02254 ; BADD_D02255 | |||
| SuperDrug ATC ID |
N02AX02
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| SuperDrug CAS ID |
cas=027203925
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | 5-HT 2C receptor (HTR2C) | Target Info | Modulator | [3] |
| KEGG Pathway | Calcium signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| Gap junction | ||||
| Serotonergic synapse | ||||
| Inflammatory mediator regulation of TRP channels | ||||
| Panther Pathway | 5HT2 type receptor mediated signaling pathway | |||
| Reactome | Serotonin receptors | |||
| G alpha (q) signalling events | ||||
| WikiPathways | Serotonin Receptor 2 and ELK-SRF/GATA4 signaling | |||
| Monoamine GPCRs | ||||
| GPCRs, Class A Rhodopsin-like | ||||
| Gastrin-CREB signalling pathway via PKC and MAPK | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8286). | |||
| REF 2 | Local effect of tramadol on formalin evoked flinching behavior in rats. Rev Bras Anestesiol. 2008 Jul-Aug;58(4):375-9, 371-5. | |||
| REF 3 | The inhibitory effects of tramadol on 5-hydroxytryptamine type 2C receptors expressed in Xenopus oocytes. Anesth Analg. 2004 May;98(5):1401-6, table of contents. | |||
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