Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D05HFU
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| Former ID |
DIB000638
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| Drug Name |
TGX-6B4
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| Synonyms |
Antiglycoprotein 1b monoclonal antibodies, CuraGen; GPIb-blocking MAb, Thromb-X; GPIb-blocking Fab fragment (thrombosis), Thromb-X
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| Drug Type |
Antibody
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| Indication | Thrombosis [ICD-11: DB61-GB90; ICD-10: I80-I82] | Preclinical | [1] | |
| Company |
ThromboGenics NV
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Platelet glycoprotein Ib alpha (CD42b) | Target Info | . | [2] |
| KEGG Pathway | ECM-receptor interaction | |||
| Platelet activation | ||||
| Hematopoietic cell lineage | ||||
| Panther Pathway | Blood coagulation | |||
| Pathway Interaction Database | Beta2 integrin cell surface interactions | |||
| Reactome | Intrinsic Pathway of Fibrin Clot Formation | |||
| GP1b-IX-V activation signalling | ||||
| Platelet Adhesion to exposed collagen | ||||
| WikiPathways | Platelet Aggregation (Plug Formation) | |||
| Platelet Adhesion to exposed collagen | ||||
| GP1b-IX-V activation signalling | ||||
| Formation of Fibrin Clot (Clotting Cascade) | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800015808) | |||
| REF 2 | Antithrombotic effect of platelet glycoprotein Ib-blocking monoclonal antibody Fab fragments in nonhuman primates. Arterioscler Thromb Vasc Biol. 2000 May;20(5):1347-53. | |||
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