Drug Information
Drug General Information | Top | |||
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Drug ID |
D05IVZ
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Former ID |
DIB010028
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Drug Name |
RU-33965
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Synonyms |
RU-33965; RU 33965; 122321-05-5; AC1L2W1Z; SCHEMBL195494; DTXSID50153570; 6H-Imidazo(1,5-a)(1,4)benzodiazepin-6-one, 3-(cyclopropylcarbonyl)-4,5-dihydro-5-methyl-
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Drug Type |
Small molecular drug
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Indication | Alzheimer disease [ICD-11: 8A20; ICD-10: G30, G30.9; ICD-9: 331] | Terminated | [1] | |
Company |
Aventis Pharma AG
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Structure |
Download2D MOL |
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Formula |
C16H15N3O2
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Canonical SMILES |
CN1CC2=C(N=CN2C3=CC=CC=C3C1=O)C(=O)C4CC4
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InChI |
1S/C16H15N3O2/c1-18-8-13-14(15(20)10-6-7-10)17-9-19(13)12-5-3-2-4-11(12)16(18)21/h2-5,9-10H,6-8H2,1H3
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InChIKey |
KNOYNQIVNYWKJR-UHFFFAOYSA-N
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CAS Number |
CAS 122321-05-5
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | GABA(A) receptor gamma-3 (GABRG3) | Target Info | Modulator | [2], [3], [4] |
KEGG Pathway | Neuroactive ligand-receptor interaction | |||
Retrograde endocannabinoid signaling | ||||
GABAergic synapse | ||||
Morphine addiction | ||||
Nicotine addiction | ||||
Reactome | Ligand-gated ion channel transport | |||
GABA A receptor activation | ||||
WikiPathways | SIDS Susceptibility Pathways | |||
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | ||||
Iron uptake and transport |
References | Top | |||
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REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001729) | |||
REF 2 | Discriminative stimulus properties of RU 33965, a benzodiazepine receptor weak partial inverse agonist. Pharmacol Biochem Behav. 1992 Oct;43(2):583-8. | |||
REF 3 | The effects of RU 33965 and RU 34030, two new 3-cyclopropyl carbonyl imidazobenzodiazepines, on GABAA receptor-mediated synaptic transmission in ce... Gen Pharmacol. 1994 May;25(3):589-97. | |||
REF 4 | Effects of benzodiazepine receptor inverse agonists and nicotine on behavioral vigilance in senescent rats. J Gerontol A Biol Sci Med Sci. 1996 May;51(3):B225-31. |
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