Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D05KEE
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| Former ID |
DIB018763
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| Drug Name |
AFD(R)
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| Synonyms |
AFD(R); GTPL2937; CHEMBL382739; SCHEMBL12084862; Phosphoric acid (R)-2-methyl-2-amino-4-(4-heptyloxyphenyl)butyl ester; [(2R)-2-amino-4-(4-heptoxyphenyl)-2-methylbutyl] dihydrogen phosphate
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL
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| Formula |
C18H32NO5P
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| Canonical SMILES |
CCCCCCCOC1=CC=C(C=C1)CCC(C)(COP(=O)(O)O)N
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| InChI |
1S/C18H32NO5P/c1-3-4-5-6-7-14-23-17-10-8-16(9-11-17)12-13-18(2,19)15-24-25(20,21)22/h8-11H,3-7,12-15,19H2,1-2H3,(H2,20,21,22)/t18-/m1/s1
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| InChIKey |
NMRLBSIYIBOLLJ-GOSISDBHSA-N
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Sphingosine-1-phosphate receptor 1 (S1PR1) | Target Info | Agonist | [2] |
| Sphingosine-1-phosphate receptor 3 (S1PR3) | Target Info | Agonist | [2] | |
| Sphingosine-1-phosphate receptor 4 (S1PR4) | Target Info | Agonist | [3] | |
| Sphingosine-1-phosphate receptor 5 (S1PR5) | Target Info | Agonist | [3] | |
| KEGG Pathway | Sphingolipid signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| FoxO signaling pathway | ||||
| NetPath Pathway | IL4 Signaling Pathway | |||
| TGF_beta_Receptor Signaling Pathway | ||||
| IL2 Signaling Pathway | ||||
| Pathway Interaction Database | S1P4 pathway | |||
| S1P5 pathway | ||||
| Sphingosine 1-phosphate (S1P) pathway | ||||
| S1P3 pathway | ||||
| Fc-epsilon receptor I signaling in mast cells | ||||
| S1P1 pathway | ||||
| PDGFR-beta signaling pathway | ||||
| Reactome | G alpha (i) signalling events | |||
| Lysosphingolipid and LPA receptors | ||||
| WikiPathways | Signal Transduction of S1P Receptor | |||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| Small Ligand GPCRs | ||||
| GPCRs, Other | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2937). | |||
| REF 2 | The immune modulator FTY720 targets sphingosine 1-phosphate receptors. J Biol Chem. 2002 Jun 14;277(24):21453-7. | |||
| REF 3 | Sphingosine 1-phosphate (S1P) receptor subtypes S1P1 and S1P3, respectively, regulate lymphocyte recirculation and heart rate. J Biol Chem. 2004 Apr 2;279(14):13839-48. | |||
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