Drug Information
Drug General Information | Top | |||
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Drug ID |
D05WSP
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Former ID |
DNC007885
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Drug Name |
UK-396082
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Synonyms |
UK-396082; UNII-2Q5861SUIG; UK-396,082; UK 396082; 2Q5861SUIG; CHEMBL398110; 400044-47-5; (2s)-5-Amino-2-[(1-Propyl-1h-Imidazol-4-Yl)methyl]pentanoic Acid; SCHEMBL3841442; GTPL8657; DTXSID70193074; BDBM50226610; DB12099; compound 21 [PMID: 17990866]; (2S)-5-amino-2-[(1-propylimidazol-4-yl)methyl]pentanoic acid; (S)-5-amino-2-((1-propyl-1H-imidazol-4-yl)methyl)pentanoic acid; (S)-2-(1-Propyl-1H-imidazole-4-ylmethyl)-5-aminopentanoic acid; 1H-Imidazole-4-propanoic acid, alpha-(3-aminopropyl)-1-propyl-, (alphaS)-
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Drug Type |
Small molecular drug
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Indication | Thrombosis [ICD-11: DB61-GB90; ICD-10: I80-I82] | Phase 1 | [1], [2] | |
Structure |
Download2D MOL |
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Formula |
C12H21N3O2
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Canonical SMILES |
CCCN1C=C(N=C1)CC(CCCN)C(=O)O
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InChI |
1S/C12H21N3O2/c1-2-6-15-8-11(14-9-15)7-10(12(16)17)4-3-5-13/h8-10H,2-7,13H2,1H3,(H,16,17)/t10-/m0/s1
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InChIKey |
OTDGPKRCQXSTPV-JTQLQIEISA-N
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CAS Number |
CAS 400044-47-5
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PubChem Compound ID | ||||
PubChem Substance ID |
Target and Pathway | Top | |||
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Target(s) | Carboxypeptidase B2 (CPB2) | Target Info | Inhibitor | [3] |
KEGG Pathway | Complement and coagulation cascades | |||
Pancreatic secretion | ||||
Protein digestion and absorption | ||||
Panther Pathway | Plasminogen activating cascade | |||
Reactome | Metabolism of Angiotensinogen to Angiotensins | |||
WikiPathways | Complement and Coagulation Cascades |
References | Top | |||
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REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8657). | |||
REF 2 | ClinicalTrials.gov (NCT01091532) A Study In Healthy People Of Multiple Doses Of UK-396,082 Given By Mouth, To Investigate The Safety, Toleration And Time Course Of Blood Concentration Of UK-396,082 And Its Effects.. U.S. National Institutes of Health. | |||
REF 3 | Oxygenated analogues of UK-396082 as inhibitors of activated thrombin activatable fibrinolysis inhibitor. Bioorg Med Chem Lett. 2010 Jan 1;20(1):92-6. |
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