Drug Information | Therapeutic Target Database

Drug General Information

Drug ID

D05WYW

Former ID

DIB013338

Drug Name

L-373890

Indication

Thrombosis [ICD-11: DB61-GB90; ICD-10: I80-I82]

Terminated

[1]

Company

Merck & Co Inc

Structure

Download

2D MOL

Target and Pathway

Target(s)

Coagulation factor IIa (F2)

Target Info

Inhibitor

[2]

KEGG Pathway

Neuroactive ligand-receptor interaction

Complement and coagulation cascades

Regulation of actin cytoskeleton

NetPath Pathway

TCR Signaling Pathway

Panther Pathway

Blood coagulation

Pathwhiz Pathway

Vitamin K Metabolism

Coagulation

Pathway Interaction Database

Thrombin/protease-activated receptor (PAR) pathway

Angiopoietin receptor Tie2-mediated signaling

FOXA2 and FOXA3 transcription factor networks

PAR4-mediated thrombin signaling events

Syndecan-4-mediated signaling events

PAR1-mediated thrombin signaling events

Reactome

Intrinsic Pathway of Fibrin Clot Formation

Common Pathway of Fibrin Clot Formation

Gamma-carboxylation of protein precursors

Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus

Removal of aminoterminal propeptides from gamma-carboxylated proteins

Cell surface interactions at the vascular wall

Peptide ligand-binding receptors

Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)

G alpha (q) signalling events

Thrombin signalling through proteinase activated receptors (PARs)

WikiPathways

Complement and Coagulation Cascades

Regulation of Actin Cytoskeleton

IL1 and megakaryotyces in obesity

Regulation of Insulin-like Growth Factor (IGF) Transport and Uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)

PTM: gamma carboxylation, hypusine formation and arylsulfatase activation

Blood Clotting Cascade

Gastrin-CREB signalling pathway via PKC and MAPK

Thrombin signalling through proteinase activated receptors (PARs)

Platelet Aggregation (Plug Formation)

GPCR ligand binding

GPCR downstream signaling

Formation of Fibrin Clot (Clotting Cascade)

Cell surface interactions at the vascular wall

Folate Metabolism

Vitamin B12 Metabolism

Selenium Micronutrient Network

References

REF 1

Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800009558)

REF 2

L-374,087, an efficacious, orally bioavailable, pyridinone acetamide thrombin inhibitor. Bioorg Med Chem Lett. 1998 Apr 7;8(7):817-22.

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