Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D05XLD
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| Former ID |
DNC008431
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| Drug Name |
Piridronic acid
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| Synonyms |
Piridronic acid; UNII-ADD4H8T3K9; ADD4H8T3K9; CHEMBL99369; 75755-07-6; NE-97221; (1-phosphono-2-pyridin-2-ylethyl)phosphonic acid; Acido piridronico; Acide piridronique; Acidum piridronicum; Piridronic acid [INN]; NE 97221; Acido piridronico [Spanish]; Acidum piridronicum [Latin]; Acide piridronique [French]; AC1L1NEH; AC1Q7DKX; (2-(2-Pyridyl)ethylidene)diphosphonic acid; SCHEMBL223779; GTPL3183; DTXSID50226652; ZINC1999562; BDBM50373096; NE97221; 2-(2-Pyridyl)ethylidine-1,1-bisphosphonate; Phosphonic acid, (2-(2-pyridinyl)ethylide
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C7H11NO6P2
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| Canonical SMILES |
C1=CC=NC(=C1)CC(P(=O)(O)O)P(=O)(O)O
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| InChI |
1S/C7H11NO6P2/c9-15(10,11)7(16(12,13)14)5-6-3-1-2-4-8-6/h1-4,7H,5H2,(H2,9,10,11)(H2,12,13,14)
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| InChIKey |
NGMZSXZBZNXBGX-UHFFFAOYSA-N
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| CAS Number |
CAS 75755-07-6
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Geranyltranstransferase (FDPS) | Target Info | Inhibitor | [2] |
| BioCyc | Superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate) | |||
| Superpathway of cholesterol biosynthesis | ||||
| Trans, trans-farnesyl diphosphate biosynthesis | ||||
| Geranylgeranyldiphosphate biosynthesis | ||||
| KEGG Pathway | Terpenoid backbone biosynthesis | |||
| Metabolic pathways | ||||
| Biosynthesis of antibiotics | ||||
| NetPath Pathway | TCR Signaling Pathway | |||
| Panther Pathway | Cholesterol biosynthesis | |||
| Pathwhiz Pathway | Steroid Biosynthesis | |||
| Reactome | Cholesterol biosynthesis | |||
| Activation of gene expression by SREBF (SREBP) | ||||
| WikiPathways | Activation of Gene Expression by SREBP (SREBF) | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3183). | |||
| REF 2 | Structure-activity relationships among the nitrogen containing bisphosphonates in clinical use and other analogues: time-dependent inhibition of hu... J Med Chem. 2008 Apr 10;51(7):2187-95. | |||
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