Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D06FJO
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| Former ID |
DCL000717
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| Drug Name |
Benzydamine
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| Synonyms |
Bencidamina; Benzidamina; Benzidamine; Benzindamine; Benzydaminum; Benzidamina [DCIT]; Benzydamine Monohydrochoride; C 1523; Apo-Benzydamine; Bencidamina [INN-Spanish]; Benzydamine (INN); Benzydamine [INN:BAN]; Benzydaminum [INN-Latin]; Apo-Benzydamine (TN); {3-[(1-benzyl-1H-indazol-3-yl)oxy]propyl}dimethylamine; 1-Benzyl-3-(3-(dimethylamino)propoxy)-1H-indazole; 3-(1-benzylindazol-3-yl)oxy-N,N-dimethylpropan-1-amine; 3-[(1-benzyl-1H-indazol-3-yl)oxy]-N,N-dimethylpropan-1-amine
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| Drug Type |
Small molecular drug
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| Indication | Chemotherapy or radiotherapy-induced mucositis [ICD-11: DA42-DA60] | Discontinued in Phase 2 | [1] | |
| Therapeutic Class |
Analgesics
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| Company |
Camurus
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| Structure |
 |
Download2D MOL |
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| Formula |
C19H23N3O
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| Canonical SMILES |
CN(C)CCCOC1=NN(C2=CC=CC=C21)CC3=CC=CC=C3
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| InChI |
1S/C19H23N3O/c1-21(2)13-8-14-23-19-17-11-6-7-12-18(17)22(20-19)15-16-9-4-3-5-10-16/h3-7,9-12H,8,13-15H2,1-2H3
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| InChIKey |
CNBGNNVCVSKAQZ-UHFFFAOYSA-N
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| CAS Number |
CAS 642-72-8
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| PubChem Compound ID | ||||
| PubChem Substance ID |
3249272, 7363241, 8159401, 10531547, 11112291, 11466325, 11467445, 11486189, 14874196, 29280766, 47275667, 47573479, 47720705, 48394035, 49698422, 49834400, 49982452, 50100409, 51091839, 57327692, 76715658, 77054122, 85788423, 88727191, 92309318, 92714382, 93625695, 103172857, 103993136, 104329316, 117474939, 117522969, 117843309, 125324610, 126624183, 126674680, 127649080, 131813289, 134976246, 137001338, 142768192, 144054864, 160657813, 162186786, 166244320, 176484560, 179149820, 184644018, 198937676, 223365688
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| ChEBI ID |
CHEBI:94563
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| ADReCS Drug ID | BADD_D00246 | |||
| SuperDrug ATC ID |
A01AD02; G02CC03; M01AX07; M02AA05
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| SuperDrug CAS ID |
cas=000642728
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| Interaction between the Drug and Microbe | Top | |||
|---|---|---|---|---|
| The Abundace of Studied Microbe(s) Regulated by Drug | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Verrucomicrobiales | ||||
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Studied Microbe: Akkermansia muciniphila
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Akkermansia muciniphila was decreased by Benzydamine hydrochloride (adjusted p-values: 5.85E-04). | |||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Prostaglandin G/H synthase (COX) | Target Info | Inhibitor | [1] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Emerging drugs for chemotherapy-induced mucositis. Expert Opin Emerg Drugs. 2008 Sep;13(3):511-22. | |||
| REF 2 | Extensive impact of non-antibiotic drugs on human gut bacteria. Nature. 2018 Mar 29;555(7698):623-628. | |||
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