Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D06HIO
|
|||
| Former ID |
DIB000628
|
|||
| Drug Name |
Istaroxime
|
|||
| Synonyms |
Debio-0614; PST-2107; PST-2744; PST-2915; ST-2744; Digitalis-like compounds, Sigma-Tau; Sodium/potassium-ATPase inhibitors (infusion, cardiac failure), Sigma-Tau/Debiopharm; Na(+)-/K(+)-ATPase inhibitors (cardiac failure), Sigma-Tau; Na(+)-/K(+)-ATPase inhibitors (infusion, cardiac failure), Sigma-Tau/ Debiopharm
Click to Show/Hide
|
|||
| Drug Type |
Small molecular drug
|
|||
| Indication | Cardiac disease [ICD-11: BA00-BE2Z; ICD-10: I50] | Discontinued in Phase 2 | [1] | |
| Company |
Sigma-Tau Pharmaceuticals
|
|||
| Structure |
 |
Download2D MOL |
||
| Formula |
C21H32N2O3
|
|||
| Canonical SMILES |
CC12CCC(=NOCCN)CC1C(=O)CC3C2CCC4(C3CCC4=O)C
|
|||
| InChI |
1S/C21H32N2O3/c1-20-7-5-13(23-26-10-9-22)11-17(20)18(24)12-14-15-3-4-19(25)21(15,2)8-6-16(14)20/h14-17H,3-12,22H2,1-2H3/b23-13+/t14-,15-,16-,17+,20+,21-/m0/s1
|
|||
| InChIKey |
MPYLDWFDPHRTEG-PAAYLBSLSA-N
|
|||
| CAS Number |
CAS 203737-93-3
|
|||
| PubChem Compound ID | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010607) | |||
| REF 2 | Novel analogues of istaroxime, a potent inhibitor of Na+,K+-ATPase: synthesis and structure-activity relationship. J Med Chem. 2008 Aug 14;51(15):4601-8. | |||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.