Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D06PZZ
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| Former ID |
DIB018186
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| Drug Name |
[14C]TEA
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| Synonyms |
Tetraethylammonium; Tetrylammonium; TETRAETHYLAMMONIUM ION; Tetramon; tetraethylazanium; N,N,N-Triethylethanaminium; tetraethylamine; UNII-5AV7G7EIEE; Tetraetilammonio [Italian]; 66-40-0; 5AV7G7EIEE; BRN 1738225; CHEMBL9324; AMMONIUM, TETRAETHYL-; CHEBI:44296; C8H20N; Tetraetilammonio; [14C]-TEA; tetraethyl ammonium; AC1L1KAW; Lopac-T-2265; 77-98-5 (hydroxide); 71-91-0 (bromide); 56-34-8 (chloride); 68-05-3 (iodide); SCHEMBL16267; 4-04-00-00331 (Beilstein Handbook Reference); NEt4(+); GTPL4575; GTPL2343; Ethanaminium,; [14C]-TEA ; tetraethylammonium
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1], [2] | |
| Structure |
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Download2D MOL
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| Formula |
C8H20N+
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| Canonical SMILES |
CC[N+](CC)(CC)CC
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| InChI |
1S/C8H20N/c1-5-9(6-2,7-3)8-4/h5-8H2,1-4H3/q+1
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| InChIKey |
CBXCPBUEXACCNR-UHFFFAOYSA-N
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| CAS Number |
CAS 66-40-0
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| PubChem Compound ID | ||||
| ChEBI ID |
CHEBI:44296
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Aquaporin-1 (AQP1) | Target Info | Inhibitor | [3] |
| Calcium-activated potassium channel KCa2.1 (KCNN1) | Target Info | Blocker (channel blocker) | [4] | |
| Calcium-activated potassium channel KCa2.2 (KCNN2) | Target Info | Blocker (channel blocker) | [4] | |
| Calcium-activated potassium channel KCa2.3 (KCNN3) | Target Info | Blocker (channel blocker) | [4] | |
| Calcium-activated potassium channel KCa4.1 (KCNT1) | Target Info | Blocker (channel blocker) | [5] | |
| Calcium-activated potassium channel KCa4.2 (KCNT2) | Target Info | Blocker (channel blocker) | [6] | |
| Calcium-activated potassium channel KCa5.1 (KCNU1) | Target Info | Blocker (channel blocker) | [7] | |
| Charybdotoxin receptor beta-4 (BKbeta4) | Target Info | Inhibitor | [8] | |
| Inward rectifier potassium channel Kir2.3 (KCNJ4) | Target Info | Blocker (channel blocker) | [9] | |
| Multidrug and toxin extrusion protein 2 (MATE2) | Target Info | Modulator | [10] | |
| Solute carrier family 47 member 1 (SLC47A1) | Target Info | Modulator | [11] | |
| Transient receptor potential cation channel V2 (TRPV2) | Target Info | Blocker (channel blocker) | [12] | |
| Voltage-gated potassium channel Kv1.1 (KCNA1) | Target Info | Blocker (channel blocker) | [13] | |
| Voltage-gated potassium channel Kv1.2 (KCNA2) | Target Info | Blocker (channel blocker) | [13] | |
| Voltage-gated potassium channel Kv1.3 (KCNA3) | Target Info | Blocker (channel blocker) | [13] | |
| Voltage-gated potassium channel Kv1.5 (KCNA5) | Target Info | Blocker (channel blocker) | [13] | |
| Voltage-gated potassium channel Kv1.6 (KCNA6) | Target Info | Blocker (channel blocker) | [14] | |
| Voltage-gated potassium channel Kv1.7 (KCNA7) | Target Info | Blocker (channel blocker) | [15] | |
| Voltage-gated potassium channel Kv1.8 (KCNA10) | Target Info | Blocker (channel blocker) | [16] | |
| Voltage-gated potassium channel Kv2.1 (KCNB1) | Target Info | Blocker (channel blocker) | [17] | |
| Voltage-gated potassium channel Kv2.2 (KCNB2) | Target Info | Blocker (channel blocker) | [18] | |
| Voltage-gated potassium channel Kv3.1 (KCNC1) | Target Info | Blocker (channel blocker) | [13] | |
| Voltage-gated potassium channel Kv3.2 (KCNC2) | Target Info | Blocker (channel blocker) | [19] | |
| Voltage-gated potassium channel Kv3.3 (KCNC3) | Target Info | Blocker (channel blocker) | [20] | |
| Voltage-gated potassium channel Kv3.4 (KCNC4) | Target Info | Blocker (channel blocker) | [21] | |
| Voltage-gated potassium channel Kv4.1 (KCND1) | Target Info | Blocker (channel blocker) | [22] | |
| Voltage-gated potassium channel Kv7.2 (KCNQ2) | Target Info | Blocker (channel blocker) | [23] | |
| Voltage-gated potassium channel Kv7.3 (KCNQ3) | Target Info | Blocker (channel blocker) | [24] | |
| Voltage-gated potassium channel Kv7.4 (KCNQ4) | Target Info | Blocker (channel blocker) | [25] | |
| Voltage-gated potassium channel Kv7.5 (KCNQ5) | Target Info | Blocker (channel blocker) | [26] | |
| KEGG Pathway | Cholinergic synapse | |||
| cGMP-PKG signaling pathway | ||||
| Vascular smooth muscle contraction | ||||
| Insulin secretion | ||||
| Salivary secretion | ||||
| Pancreatic secretion | ||||
| Panther Pathway | Muscarinic acetylcholine receptor 1 and 3 signaling pathway | |||
| Pathwhiz Pathway | Muscle/Heart Contraction | |||
| Reactome | Voltage gated Potassium channels | |||
| Interaction between L1 and Ankyrins | ||||
| cGMP effects | ||||
| Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | ||||
| WikiPathways | Potassium Channels | |||
| L1CAM interactions | ||||
| BDNF signaling pathway | ||||
| Platelet homeostasis | ||||
| Calcium Regulation in the Cardiac Cell | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4575). | |||
| REF 2 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2343). | |||
| REF 3 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 688). | |||
| REF 4 | Small conductance calcium-activated potassium channels: from structure to function. Prog Neurobiol. 2010 Jul;91(3):242-55. | |||
| REF 5 | For K+ channels, Na+ is the new Ca2+. Trends Neurosci. 2005 Aug;28(8):422-8. | |||
| REF 6 | Opposite regulation of Slick and Slack K+ channels by neuromodulators. J Neurosci. 2006 May 10;26(19):5059-68. | |||
| REF 7 | Block of mouse Slo1 and Slo3 K+ channels by CTX, IbTX, TEA, 4-AP and quinidine. Channels (Austin). 2010 Jan-Feb;4(1):22-41. | |||
| REF 8 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 380). | |||
| REF 9 | Cloning and expression of a novel human brain inward rectifier potassium channel. J Biol Chem. 1994 Aug 12;269(32):20468-74. | |||
| REF 10 | Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin extrusions/H(+)-organic cation antiporters. Biochem Pharmacol. 2007 Jul 15;74(2):359-71. | |||
| REF 11 | Molecular cloning, functional characterization and tissue distribution of rat H+/organic cation antiporter MATE1. Pharm Res. 2006 Aug;23(8):1696-701. | |||
| REF 12 | Pharmacological characterization and molecular determinants of the activation of transient receptor potential V2 channel orthologs by 2-aminoethoxy... Mol Pharmacol. 2007 Nov;72(5):1258-68. | |||
| REF 13 | Pharmacological characterization of five cloned voltage-gated K+ channels, types Kv1.1, 1.2, 1.3, 1.5, and 3.1, stably expressed in mammalian cell lines. Mol Pharmacol. 1994 Jun;45(6):1227-34. | |||
| REF 14 | Cloning and expression of a human voltage-gated potassium channel. A novel member of the RCK potassium channel family. EMBO J. 1990 Jun;9(6):1749-56. | |||
| REF 15 | Characterisation of the human voltage-gated potassium channel gene, KCNA7, a candidate gene for inherited cardiac disorders, and its exclusion as cause of progressive familial heart block I (PFHBI). Eur J Hum Genet. 2002 Jan;10(1):36-43. | |||
| REF 16 | KCNA10: a novel ion channel functionally related to both voltage-gated potassium and CNG cation channels. Am J Physiol Renal Physiol. 2000 Jun;278(6):F1013-21. | |||
| REF 17 | Modulation of Kv2.1 channel gating and TEA sensitivity by distinct domains of SNAP-25. Biochem J. 2006 Jun 1;396(2):363-9. | |||
| REF 18 | Molecular identification of a component of delayed rectifier current in gastrointestinal smooth muscles. Am J Physiol. 1998 May;274(5 Pt 1):G901-11. | |||
| REF 19 | Gating, modulation and subunit composition of voltage-gated K(+) channels in dendritic inhibitory interneurones of rat hippocampus. J Physiol. 2002 Jan 15;538(Pt 2):405-19. | |||
| REF 20 | Cloning of ShIII (Shaw-like) cDNAs encoding a novel high-voltage-activating, TEA-sensitive, type-A K+ channel. Proc Biol Sci. 1992 Apr 22;248(1321):9-18. | |||
| REF 21 | Characterization of a Shaw-related potassium channel family in rat brain. EMBO J. 1992 Jul;11(7):2473-86. | |||
| REF 22 | Endogenous Kv channels in human embryonic kidney (HEK-293) cells. Mol Cell Biochem. 2002 Sep;238(1-2):69-79. | |||
| REF 23 | Retigabine, a novel anti-convulsant, enhances activation of KCNQ2/Q3 potassium channels. Mol Pharmacol. 2000 Sep;58(3):591-600. | |||
| REF 24 | Differential tetraethylammonium sensitivity of KCNQ1-4 potassium channels. Br J Pharmacol. 2000 Feb;129(3):413-5. | |||
| REF 25 | Homomeric and heteromeric assembly of KCNQ (Kv7) K+ channels assayed by total internal reflection fluorescence/fluorescence resonance energy transfer and patch clamp analysis. J Biol Chem. 2008 Nov 7;283(45):30668-76. | |||
| REF 26 | KCNQ5, a novel potassium channel broadly expressed in brain, mediates M-type currents. J Biol Chem. 2000 Aug 4;275(31):24089-95. | |||
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