Drug Information
Drug General Information | Top | |||
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Drug ID |
D06VZE
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Former ID |
DIB018342
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Drug Name |
[3H]mibolerone
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Synonyms |
Mibolerone; MIBOLERONE; 3704/9/4; Miboleronum; Mibolerona; Cheque; U-10,997; UNII-9OGY4BOR8D; NSC 72260; 9OGY4BOR8D; U 10997; Matenon; Miboleron; 17-beta-Hydroxy-7-alpha,17-dimethylestr-4-en-3-one; CHEBI:34849; U-10997; 17beta-Hydroxy-7alpha,17-dimethylestr-4-en-3-one; (7alpha,17beta)-17-hydroxy-7,17-dimethylestr-4-en-3-one; 7alpha-17alpha-dimethyl-19-nortestosterone; CDB 904; Cheque (Veterinary)
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1], [2] | |
Structure |
Download2D MOL |
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Formula |
C20H30O2
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Canonical SMILES |
CC1CC2=CC(=O)CCC2C3C1C4CCC(C4(CC3)C)(C)O
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InChI |
1S/C20H30O2/c1-12-10-13-11-14(21)4-5-15(13)16-6-8-19(2)17(18(12)16)7-9-20(19,3)22/h11-12,15-18,22H,4-10H2,1-3H3/t12-,15+,16-,17+,18-,19+,20+/m1/s1
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InChIKey |
PTQMMNYJKCSPET-OMHQDGTGSA-N
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CAS Number |
CAS 3704-09-4
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PubChem Compound ID | ||||
ChEBI ID |
CHEBI:34849
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Target and Pathway | Top | |||
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Target(s) | Androgen receptor (AR) | Target Info | Inhibitor | [3] |
Androgen receptor messenger RNA (AR mRNA) | Target Info | Agonist | [4] | |
KEGG Pathway | Oocyte meiosis | |||
Pathways in cancer | ||||
Prostate cancer | ||||
NetPath Pathway | EGFR1 Signaling Pathway | |||
AndrogenReceptor Signaling Pathway | ||||
FSH Signaling Pathway | ||||
Pathway Interaction Database | Regulation of nuclear SMAD2/3 signaling | |||
Coregulation of Androgen receptor activity | ||||
Regulation of Androgen receptor activity | ||||
Nongenotropic Androgen signaling | ||||
Regulation of nuclear beta catenin signaling and target gene transcription | ||||
FOXA1 transcription factor network | ||||
Notch-mediated HES/HEY network | ||||
Reactome | Nuclear Receptor transcription pathway | |||
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 | ||||
WikiPathways | SIDS Susceptibility Pathways | |||
Integrated Pancreatic Cancer Pathway | ||||
Prostate Cancer | ||||
Integrated Breast Cancer Pathway | ||||
Nuclear Receptors | ||||
Androgen receptor signaling pathway |
References | Top | |||
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REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3456). | |||
REF 2 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2859). | |||
REF 3 | Design, synthesis, and pharmacological characterization of 4-[4, 4-dimethyl-3-(4-hydroxybutyl)-5-oxo-2-thioxo-1-imidazolidinyl]- 2-iodobenzonitrile... J Med Chem. 2000 Aug 24;43(17):3344-7. | |||
REF 4 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 628). |
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