Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D06WHL
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| Former ID |
DIB004606
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| Drug Name |
NS-257
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| Synonyms |
PD-144216
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| Indication | Cerebrovascular ischaemia [ICD-11: 8B1Z; ICD-10: I67.8; ICD-9: 434.91] | Terminated | [1] | |
| Company |
NeuroSearch A/S
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| Structure |
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Download2D MOL |
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| Formula |
C13H16N4O4S
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| Canonical SMILES |
CN1CC2=C(C=C3C(=C2C1)NC(=C3N=O)O)S(=O)(=O)N(C)C
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| InChI |
1S/C13H16N4O4S/c1-16(2)22(20,21)10-4-7-11(14-13(18)12(7)15-19)9-6-17(3)5-8(9)10/h4,14,18H,5-6H2,1-3H3
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| InChIKey |
ZPJJGAUEQIVPRW-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Glutamate receptor AMPA (GRIA) | Target Info | Antagonist | [2] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002246) | |||
| REF 2 | Characterization of the binding of [3H]NS 257, a novel competitive AMPA receptor antagonist, to rat brain membranes and brain sections. J Neurochem. 1995 Sep;65(3):1264-73. | |||
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