Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D07FTI
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| Former ID |
DIB021255
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| Drug Name |
zinc pyrithione
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| Synonyms |
BCP13412
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL
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| Formula |
C10H8N2O2S2Zn
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| Canonical SMILES |
C1=CC=[N+](C(=C1)[S-])[O-].C1=CC=[N+](C(=C1)[S-])[O-].[Zn+2]
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| InChI |
1S/2C5H5NOS.Zn/c2*7-6-4-2-1-3-5(6)8;/h2*1-4,8H;/q;;+2/p-2
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| InChIKey |
OTPSWLRZXRHDNX-UHFFFAOYSA-L
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| CAS Number |
CAS 13463-41-7
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Voltage-gated potassium channel Kv7.1 (KCNQ1) | Target Info | Activator | [2] |
| Voltage-gated potassium channel Kv7.2 (KCNQ2) | Target Info | Activator | [2] | |
| Voltage-gated potassium channel Kv7.4 (KCNQ4) | Target Info | Activator | [2] | |
| Voltage-gated potassium channel Kv7.5 (KCNQ5) | Target Info | Activator | [2] | |
| KEGG Pathway | Cholinergic synapse | |||
| Adrenergic signaling in cardiomyocytes | ||||
| Gastric acid secretion | ||||
| Pancreatic secretion | ||||
| Protein digestion and absorption | ||||
| Vibrio cholerae infection | ||||
| Panther Pathway | Muscarinic acetylcholine receptor 1 and 3 signaling pathway | |||
| Pathwhiz Pathway | Muscle/Heart Contraction | |||
| Reactome | Voltage gated Potassium channels | |||
| Interaction between L1 and Ankyrins | ||||
| WikiPathways | Potassium Channels | |||
| SIDS Susceptibility Pathways | ||||
| miR-targeted genes in muscle cell - TarBase | ||||
| miR-targeted genes in lymphocytes - TarBase | ||||
| TarBasePathway | ||||
| L1CAM interactions | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2597). | |||
| REF 2 | Zinc pyrithione-mediated activation of voltage-gated KCNQ potassium channels rescues epileptogenic mutants. Nat Chem Biol. 2007 May;3(5):287-96. | |||
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