Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D07GQA
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| Former ID |
DIB002819
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| Drug Name |
ZD-7155
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| Synonyms |
ZD-7155; CHEMBL159096; 5,7-diethyl-1-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-3,4-dihydro-1,6-naphthyridin-2-one; 5,7-Diethyl-1-{[2'-(1h-Tetrazol-5-Yl)biphenyl-4-Yl]methyl}-3,4-Dihydro-1,6-Naphthyridin-2(1h)-One; ZD 7155; Tocris-1211; NCGC00025043-01; AC1NGE69; SCHEMBL7286312; GTPL8324; CHEBI:92194; ZINC3784334; BDBM50049187; L007754; BRD-K11373525-003-01-3; ZD7; 5,7-diethyl-1-[2'-(1h-1,2,3,4-tetrazol-5-yl)-bi-phenyl-4-ylmethyl]-1,2,3,4-tetrahydro-1,6-naphthyridin-2-one
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| Drug Type |
Small molecular drug
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| Indication | Hypertension [ICD-11: BA00-BA04; ICD-9: 401] | Terminated | [1], [2] | |
| Company |
Zeneca Group plc
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| Structure |
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Download2D MOL |
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| Formula |
C26H26N6O
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| Canonical SMILES |
CCC1=CC2=C(CCC(=O)N2CC3=CC=C(C=C3)C4=CC=CC=C4C5=NNN=N5)C(=N1)CC
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| InChI |
1S/C26H26N6O/c1-3-19-15-24-22(23(4-2)27-19)13-14-25(33)32(24)16-17-9-11-18(12-10-17)20-7-5-6-8-21(20)26-28-30-31-29-26/h5-12,15H,3-4,13-14,16H2,1-2H3,(H,28,29,30,31)
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| InChIKey |
BFVNEYDCFJNLGN-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| ChEBI ID |
CHEBI:92194
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Angiotensin II receptor (AGTR) | Target Info | Modulator | [3] |
| KEGG Pathway | Calcium signaling pathway | |||
| cGMP-PKG signaling pathway | ||||
| Neuroactive ligand-receptor interaction | ||||
| Adrenergic signaling in cardiomyocytes | ||||
| Vascular smooth muscle contraction | ||||
| Renin-angiotensin system | ||||
| Renin secretion | ||||
| Pathways in cancer | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8324). | |||
| REF 2 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002281) | |||
| REF 3 | Comparative cardiovascular effects of the angiotensin II type 1 receptor antagonists ZD 7155 and losartan in the rat. J Pharm Pharmacol. 1996 Aug;48(8):829-33. | |||
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