Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D07JDC
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| Former ID |
DIB019064
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| Drug Name |
carvacrol
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| Synonyms |
CARVACROL; 5-Isopropyl-2-methylphenol; 499-75-2; Isopropyl-o-cresol; Karvakrol; o-Thymol; Antioxine; 5-Isopropyl-o-cresol; 2-p-Cymenol; 2-Hydroxy-p-cymene; Isothymol; Phenol, 2-methyl-5-(1-methylethyl)-; p-Cymen-2-ol; 2-Methyl-5-isopropylphenol; 3-Isopropyl-6-methylphenol; p-Cymene, 2-hydroxy-; 5-Isopropyl-2-methyl-phenol; 2-Methyl-5-(Propan-2-Yl)Phenol; 2-Methyl-5-(1-methylethyl)phenol; o-Cresol, 5-isopropyl-; 1-Hydroxy-2-methyl-5-isopropylbenzene; 6-Methyl-3-isopropylphenol; Phenol, 5-isopropyl-2-methyl-; Cymene-2-ol, p-
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL
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| Formula |
C10H14O
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| Canonical SMILES |
CC1=C(C=C(C=C1)C(C)C)O
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| InChI |
1S/C10H14O/c1-7(2)9-5-4-8(3)10(11)6-9/h4-7,11H,1-3H3
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| InChIKey |
RECUKUPTGUEGMW-UHFFFAOYSA-N
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| CAS Number |
CAS 499-75-2
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| PubChem Compound ID | ||||
| PubChem Substance ID |
12027, 72179, 587993, 614462, 3155675, 4965060, 8157482, 10524223, 11528571, 12055917, 15194720, 24853174, 24857025, 24900943, 29203921, 50782553, 53801081, 56369115, 57326160, 74382164, 85087098, 87565235, 88834878, 92711002, 93165944, 99246150, 103199240, 104098282, 104323093, 104669251, 117366423, 118309331, 123071442, 125351482, 126565361, 126631305, 126646199, 126669030, 128713154, 129116125, 129276130, 129577075, 131316276, 134977964, 135306122, 135610165, 135715960, 136910575, 137003575, 142269769
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| ChEBI ID |
CHEBI:3440
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Long transient receptor potential channel 7 (TRPM7) | Target Info | Blocker (channel blocker) | [2] |
| Transient receptor potential cation channel V3 (TRPV3) | Target Info | Activator | [3] | |
| KEGG Pathway | Inflammatory mediator regulation of TRP channels | |||
| Reactome | TRP channels | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2497). | |||
| REF 2 | Carvacrol is a novel inhibitor of Drosophila TRPL and mammalian TRPM7 channels. Cell Calcium. 2009 Mar;45(3):300-9. | |||
| REF 3 | Oregano, thyme and clove-derived flavors and skin sensitizers activate specific TRP channels. Nat Neurosci. 2006 May;9(5):628-35. | |||
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