Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D07JVL
|
|||
| Former ID |
DIB012028
|
|||
| Drug Name |
Diazepam
|
|||
| Synonyms |
diazepam; Valium; 439-14-5; Diazemuls; Ansiolisina; Sibazon; Relanium; Faustan; Apaurin; Stesolid; Seduxen; Methyldiazepinone; Valitran; Tranqdyn; Seduksen; Relaminal; Quiatril; Quetinil; Dipezona; Diazetard; Diazepan; Calmpose; Tranimul; Tensopam; Serenack; Paranten; Kiatrium; Domalium; Condition; Bialzepam; Ansiolin; Unisedil; Stesolin; Serenamin; Ruhsitus; Renborin; Quievita; Tranquirit; Serenzin; Neurolytril; Liberetas; Diacepan; Ceregulart; Calmocitene; Bensedin; Atensine; Apozepam; Umbrium; Sonacon; Sedipam; Levium; Diapam; Atilen; Assival; Amiprol; Diazepam (intranasal, epilepsy)
Click to Show/Hide
|
|||
| Drug Type |
Small molecular drug
|
|||
| Indication | Epilepsy [ICD-11: 8A60-8A68] | Approved | [1], [2] | |
| Company |
Archimedes Pharma Ltd
|
|||
| Structure |
 |
Download2D MOL |
||
| Formula |
C16H13ClN2O
|
|||
| Canonical SMILES |
CN1C(=O)CN=C(C2=C1C=CC(=C2)Cl)C3=CC=CC=C3
|
|||
| InChI |
1S/C16H13ClN2O/c1-19-14-8-7-12(17)9-13(14)16(18-10-15(19)20)11-5-3-2-4-6-11/h2-9H,10H2,1H3
|
|||
| InChIKey |
AAOVKJBEBIDNHE-UHFFFAOYSA-N
|
|||
| CAS Number |
CAS 439-14-5
|
|||
| PubChem Compound ID | ||||
| PubChem Substance ID |
9163, 118340, 442487, 589069, 597369, 866565, 3248698, 5349992, 7847359, 7849643, 7887249, 7945393, 7979063, 8027939, 8150113, 8151919, 10522913, 11336142, 11361381, 11372878, 11374151, 11462353, 11491595, 11492391, 14799843, 24893306, 24894120, 26719642, 29222163, 46386554, 46505210, 47440353, 47515391, 47662377, 48259330, 48413548, 48415873, 48423248, 49742658, 49854346, 50122777, 50660483, 53788455, 56313613, 57321555, 57654125, 81041007, 85788516, 85856297, 92308494
|
|||
| ChEBI ID |
CHEBI:49575
|
|||
| ADReCS Drug ID | BADD_D00648 | |||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Translocator protein (TSPO) | Target Info | Agonist | [3], [4] |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| HTLV-I infection | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3364). | |||
| REF 2 | ClinicalTrials.gov (NCT01939093) Therapeutic Effect of Quetiapine on Methamphetamine-Induced Psychosis. U.S. National Institutes of Health. | |||
| REF 3 | Translocator protein (18 kDa) mediates the pro-growth effects of diazepam on Ehrlich tumor cells in vivo. Eur J Pharmacol. 2010 Jan 25;626(2-3):131-8. | |||
| REF 4 | The alpha5(H105R) mutation impairs alpha5 selective binding properties by altered positioning of the alpha5 subunit in GABAA receptors containing t... J Neurochem. 2009 Jul;110(1):244-54. | |||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.