Drug Information
Drug General Information | Top | |||
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Drug ID |
D07KIJ
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Former ID |
DIB000465
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Drug Name |
INCB3344
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Synonyms |
INCB-3268; INCB-3344; PF-4254196; CCR2 antagonists, Incyte/Pfizer
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Drug Type |
Small molecular drug
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Indication | Arteriosclerosis [ICD-11: BD40; ICD-9: 440] | Terminated | [1], [2] | |
Company |
Incyte Corp
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Structure |
Download2D MOL |
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Formula |
C29H34F3N3O6
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Canonical SMILES |
CCOC1CN(CC1NC(=O)CNC(=O)C2=CC(=CC=C2)C(F)(F)F)C3CCC(CC3)(C4=CC5=C(C=C4)OCO5)O
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InChI |
1S/C29H34F3N3O6/c1-2-39-25-16-35(21-8-10-28(38,11-9-21)19-6-7-23-24(13-19)41-17-40-23)15-22(25)34-26(36)14-33-27(37)18-4-3-5-20(12-18)29(30,31)32/h3-7,12-13,21-22,25,38H,2,8-11,14-17H2,1H3,(H,33,37)(H,34,36)/t21?,22-,25-,28?/m0/s1
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InChIKey |
MZEOSVPWMSEFPW-XYCDVDSTSA-N
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | C-C chemokine receptor type 2 (CCR2) | Target Info | Antagonist | [3] |
KEGG Pathway | Cytokine-cytokine receptor interaction | |||
Chemokine signaling pathway | ||||
NetPath Pathway | TCR Signaling Pathway | |||
IL2 Signaling Pathway | ||||
TGF_beta_Receptor Signaling Pathway | ||||
Leptin Signaling Pathway | ||||
RANKL Signaling Pathway | ||||
Panther Pathway | Inflammation mediated by chemokine and cytokine signaling pathway | |||
Reactome | Beta defensins | |||
Chemokine receptors bind chemokines | ||||
G alpha (i) signalling events | ||||
WikiPathways | GPCRs, Class A Rhodopsin-like | |||
Defensins | ||||
Spinal Cord Injury | ||||
Peptide GPCRs | ||||
GPCR ligand binding | ||||
GPCR downstream signaling |
References | Top | |||
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REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 777). | |||
REF 2 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800035662) | |||
REF 3 | Discovery of ((1S,3R)-1-isopropyl-3-((3S,4S)-3-methoxy-tetrahydro-2H-pyran-4-ylamino)cyclopentyl)(4-(5-(trifluoromethyl)pyridazin-3-yl)piperazin-1-yl)methanone, PF-4254196, a CCR2 antagonist with an improved cardiovascular profile. Bioorg Med Chem Lett. 2011 May 1;21(9):2626-30. |
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