Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D07YLO
|
|||
| Former ID |
DNCL001735
|
|||
| Drug Name |
SDF-1
|
|||
| Synonyms |
JVS-100
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|
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| Indication | Heart failure [ICD-11: BD10-BD13; ICD-10: I50, I50.9; ICD-9: 428] | Phase 2 | [1] | |
| Peripheral arterial disease [ICD-11: BD4Z; ICD-10: I73, I73.9] | Phase 2 | [2] | ||
| Company |
Juventas Therapeutics
|
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Stromal cell-derived factor 1 (CXCL12) | Target Info | Inhibitor | [3] |
| KEGG Pathway | Cytokine-cytokine receptor interaction | |||
| Chemokine signaling pathway | ||||
| NF-kappa B signaling pathway | ||||
| Axon guidance | ||||
| Leukocyte transendothelial migration | ||||
| Intestinal immune network for IgA production | ||||
| Pathways in cancer | ||||
| Rheumatoid arthritis | ||||
| NetPath Pathway | IL-7 Signaling Pathway | |||
| TWEAK Signaling Pathway | ||||
| Panther Pathway | Axon guidance mediated by Slit/Robo | |||
| Pathway Interaction Database | CXCR4-mediated signaling events | |||
| Syndecan-4-mediated signaling events | ||||
| HIF-1-alpha transcription factor network | ||||
| Reactome | Nuclear signaling by ERBB4 | |||
| Chemokine receptors bind chemokines | ||||
| G alpha (i) signalling events | ||||
| WikiPathways | EV release from cardiac cells and their functional effects | |||
| Signaling by ERBB4 | ||||
| Allograft Rejection | ||||
| miR-targeted genes in muscle cell - TarBase | ||||
| miR-targeted genes in lymphocytes - TarBase | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT01643590) Study to Evaluate the Safety and Efficacy of JVS-100 Administered to Adults With Ischemic Heart Failure.. U.S. National Institutes of Health. | |||
| REF 2 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) | |||
| REF 3 | SDF-1 in myocardial repair. Gene Ther. 2012 Jun;19(6):583-7. | |||
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