Drug Information
Drug General Information | Top | |||
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Drug ID |
D08EQD
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Drug Name |
FGF401
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Synonyms |
Roblitinib; 1708971-55-4; FGF-401; UNII-M64JF6WMSA; M64JF6WMSA; N-[5-cyano-4-(2-methoxyethylamino)pyridin-2-yl]-7-formyl-6-[(4-methyl-2-oxopiperazin-1-yl)methyl]-3,4-dihydro-2H-1,8-naphthyridine-1-carboxamide; N-(5-cyano-4-((2-methoxyethyl)amino)pyridin-2-yl)-7-formyl-6-((4-methyl-2-oxopiperazin-1-yl)methyl)-3,4-dihydro-1,8-naphthyridine-1(2H)-carboxamide; Roblitinib [INN]; NVP-FGF401; GTPL9768; FGF 401 [WHO-DD]; CHEMBL3908979; SCHEMBL16668840; BHKDKKZMPODMIQ-UHFFFAOYSA-N; MolPort-044-756-212; BDBM209325; EX-A1341
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Indication | Hepatocellular carcinoma [ICD-11: 2C12.02; ICD-10: C22.0; ICD-9: 155] | Phase 1/2 | [1] | |
Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C00-D48; ICD-9: 140-199, 210-229] | Phase 1/2 | [1] | ||
Company |
Novartis Oncology East Hanover, NJ
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Structure |
Download2D MOL |
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Formula |
C25H30N8O4
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Canonical SMILES |
CN1CCN(C(=O)C1)CC2=C(N=C3C(=C2)CCCN3C(=O)NC4=NC=C(C(=C4)NCCOC)C#N)C=O
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InChI |
1S/C25H30N8O4/c1-31-7-8-32(23(35)15-31)14-18-10-17-4-3-6-33(24(17)29-21(18)16-34)25(36)30-22-11-20(27-5-9-37-2)19(12-26)13-28-22/h10-11,13,16H,3-9,14-15H2,1-2H3,(H2,27,28,30,36)
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InChIKey |
BHKDKKZMPODMIQ-UHFFFAOYSA-N
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CAS Number |
CAS 1708971-55-4
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | FGFR4 messenger RNA (FGFR4 mRNA) | Target Info | Antagonist | [1] |
KEGG Pathway | MAPK signaling pathway | |||
Ras signaling pathway | ||||
Rap1 signaling pathway | ||||
Endocytosis | ||||
PI3K-Akt signaling pathway | ||||
Signaling pathways regulating pluripotency of stem cells | ||||
Regulation of actin cytoskeleton | ||||
Panther Pathway | FGF signaling pathway | |||
Pathway Interaction Database | FGF signaling pathway | |||
Reactome | PI3K Cascade | |||
PIP3 activates AKT signaling | ||||
FGFR4 ligand binding and activation | ||||
Constitutive Signaling by Aberrant PI3K in Cancer | ||||
Phospholipase C-mediated cascade | ||||
FRS-mediated FGFR4 signaling | ||||
SHC-mediated cascade:FGFR4 | ||||
PI-3K cascade:FGFR4 | ||||
Negative regulation of FGFR4 signaling | ||||
RAF/MAP kinase cascade | ||||
WikiPathways | Regulation of Actin Cytoskeleton | |||
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | ||||
PIP3 activates AKT signaling | ||||
Signaling by FGFR |
References | Top | |||
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REF 1 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) |
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