Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D08GBB
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| Former ID |
DIB012153
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| Drug Name |
Valopicitabine dihydrochloride
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| Synonyms |
Valopicitabine; NM-106; NM-107; NM-283; NMC-283; Hepatitis C therapeutics, Novartis/Idenix; 2'-C-methylcytidine
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| Drug Type |
Small molecular drug
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| Indication | Virus infection [ICD-11: 1A24-1D9Z] | Phase 2 | [1] | |
| Company |
Idenix Pharmaceuticals Inc
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| Structure |
 |
Download2D MOL
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| Formula |
C15H26Cl2N4O6
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| Canonical SMILES |
CC(C)C(C(=O)OC1C(OC(C1(C)O)N2C=CC(=NC2=O)N)CO)N.Cl.Cl
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| InChI |
1S/C15H24N4O6.2ClH/c1-7(2)10(17)12(21)25-11-8(6-20)24-13(15(11,3)23)19-5-4-9(16)18-14(19)22;;/h4-5,7-8,10-11,13,20,23H,6,17H2,1-3H3,(H2,16,18,22);2*1H/t8-,10+,11-,13-,15-;;/m1../s1
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| InChIKey |
XENHXZMAOSTXGD-DSMKLBDQSA-N
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| CAS Number |
CAS 640725-71-9
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Hepatitis C virus RNA-directed RNA polymerase (HCV NS5B) | Target Info | Modulator | [2] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT00395421) Study to Evaluate Drug-drug Interaction Between Valopicitabine and Ribavirin. U.S. National Institutes of Health. | |||
| REF 2 | Valopicitabine dihydrochloride:a specific polymerase inhibitor of hepatitis C virus. Curr Opin Investig Drugs. 2007 Feb;8(2):150-8. | |||
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