Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D08GYO
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| Former ID |
DAP000986
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| Drug Name |
Procarbazine
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| Synonyms |
Ibenzmethyzin; Ibenzmethyzine; MBH; MIH; Natulan; Natulanar; PCX; Procarbazin; Procarbazina; Procarbazinum; Procarbazin [German]; Procarbazine Monohydrochloride; CB 400-497; Indicarb (TN); Matulane (TN); Natulan (TN); Procarbazina [INN-Spanish]; Procarbazine (INN); Procarbazine [INN:BAN]; Procarbazinum [INN-Latin];Ro 4-6467; SRI-10847; Ro 4-6467/1; N-4-Isopropylcarbamoylbenzyl-N'-methylhydrazine; N-Isopropyl-4-[(2-methylhydrazino)methyl]benzamide; P-(2-Methylhydrazinomethyl)-N-isopropylbenzamide; N-Isopropyl-p-(2-methylhydrazinomethyl)-benzamide; P-(N'-Methylhydrazinomethyl)-N-isopropylbenzamide; N-(1-Methylethyl)-4-[(2-methylhydrazino)methyl]benzamide; N-Isopropyl-alpha-(2-methylhydrazino)-p-toluamide; N-(1-Methylethyl)-4-((2-methylhydrazino)methyl)benzamide; Benzamide, N-(1-methylethyl)-4-((2-methylhydrazino)methyl)-(9CI); 1-Methyl-2-(p-(isopropylcarbamoyl)benzyl)hydrazine; 2-(p-Isopropylcarbamoylbenzyl)-1-methylhydrazine; 4-((2-Methylhydrazino)methyl)-N-isopropylbenzamide; 4-[(2-methylhydrazinyl)methyl]-N-propan-2-ylbenzamide
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| Drug Type |
Small molecular drug
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| Indication | Hodgkin lymphoma [ICD-11: 2B30; ICD-10: C81, C81.9] | Approved | [1], [2] | |
| Therapeutic Class |
Anticancer Agents
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| Company |
Sigma-Tau Pharmaceuticals
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| Structure |
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Download2D MOL |
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| Formula |
C12H19N3O
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| Canonical SMILES |
CC(C)NC(=O)C1=CC=C(C=C1)CNNC
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| InChI |
1S/C12H19N3O/c1-9(2)15-12(16)11-6-4-10(5-7-11)8-14-13-3/h4-7,9,13-14H,8H2,1-3H3,(H,15,16)
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| InChIKey |
CPTBDICYNRMXFX-UHFFFAOYSA-N
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| CAS Number |
CAS 671-16-9
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| PubChem Compound ID | ||||
| PubChem Substance ID |
9606, 5227622, 7980389, 8153026, 10532324, 11112335, 11446055, 11451557, 11467140, 11468260, 11486848, 15195970, 29223993, 46507706, 47440427, 47736658, 47810931, 48259429, 48414372, 48416472, 49699412, 49857646, 50100422, 53790978, 57288818, 57322522, 60975981, 75023517, 92309185, 92720556, 93166341, 96025109, 103411217, 104224963, 104307787, 119525894, 125564988, 126619890, 126653077, 126667406, 127660052, 134338256, 134977726, 136342514, 137001449, 140349398, 144076104, 144212055, 152030630, 160655721
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| ChEBI ID |
CHEBI:71417
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| ADReCS Drug ID | BADD_D01846 ; BADD_D01847 | |||
| SuperDrug ATC ID |
L01XB01
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| SuperDrug CAS ID |
cas=000671169
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| Interaction between the Drug and Microbe | Top | |||
|---|---|---|---|---|
| The Metabolism of Drug Affected by Studied Microbe(s) | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bacteroidales | ||||
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Studied Microbe: Bacteroides coprophilus DSM 18228
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Procarbazine can be metabolized by Bacteroides coprophilus DSM 18228 (log2FC = -0.341; p = 0.006). | |||
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Studied Microbe: Bacteroides dorei DSM 17855
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Procarbazine can be metabolized by Bacteroides dorei DSM 17855 (log2FC = -0.577; p = 0.009). | |||
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Studied Microbe: Bacteroides fragilis ATCC43859
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Procarbazine can be metabolized by Bacteroides fragilis ATCC43859 (log2FC = -0.969; p = 0.013). | |||
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Studied Microbe: Bacteroides fragilis HMW 610
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Procarbazine can be metabolized by Bacteroides fragilis HMW 610 (log2FC = -0.829; p = 0.018). | |||
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Studied Microbe: Bacteroides fragilis HMW 615
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|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Procarbazine can be metabolized by Bacteroides fragilis HMW 615 (log2FC = -0.761; p = 0.011). | |||
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Studied Microbe: Bacteroides fragilis NCTC 9343
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|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Procarbazine can be metabolized by Bacteroides fragilis NCTC 9343 (log2FC = -0.34; p = 0.03). | |||
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Studied Microbe: Bacteroides fragilis str. 3986 T(B)9
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Procarbazine can be metabolized by Bacteroides fragilis str. 3986 T(B)9 (log2FC = -0.598; p = 0.017). | |||
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Studied Microbe: Bacteroides ovatus ATCC 8483
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Procarbazine can be metabolized by Bacteroides ovatus ATCC 8483 (log2FC = -0.356; p = 0.021). | |||
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Studied Microbe: Bacteroides stercoris ATCC 43183
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Procarbazine can be metabolized by Bacteroides stercoris ATCC 43183 (log2FC = -0.47; p = 0.002). | |||
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Studied Microbe: Bacteroides thetaiotaomicron 7330
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Procarbazine can be metabolized by Bacteroides thetaiotaomicron 7330 (log2FC = -0.332; p = 0.012). | |||
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Studied Microbe: Bacteroides thetaiotaomicron VPI-5482
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Procarbazine can be metabolized by Bacteroides thetaiotaomicron VPI-5482 (log2FC = -0.42; p = 0.044). | |||
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Studied Microbe: Bacteroides uniformis ATCC 8492
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Procarbazine can be metabolized by Bacteroides uniformis ATCC 8492 (log2FC = -0.634; p = 0.029). | |||
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Studied Microbe: Bacteroides vulgatus ATCC 8482
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Procarbazine can be metabolized by Bacteroides vulgatus ATCC 8482 (log2FC = -0.654; p = 0.025). | |||
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Studied Microbe: Bacteroides xylanisolvens DSM18836
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Procarbazine can be metabolized by Bacteroides xylanisolvens DSM18836 (log2FC = -0.497; p = 0.007). | |||
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Studied Microbe: Odoribacter splanchnicus
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Procarbazine can be metabolized by Odoribacter splanchnicus (log2FC = -0.542; p = 0.025). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Eubacteriales | ||||
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Studied Microbe: Clostridium sp.
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|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Procarbazine can be metabolized by Clostridium sp. (log2FC = -0.425; p = 0.015). | |||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Human Deoxyribonucleic acid (hDNA) | Target Info | . | [4] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7278). | |||
| REF 2 | FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 016785. | |||
| REF 3 | Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467. | |||
| REF 4 | Brca2/Xrcc2 dependent HR, but not NHEJ, is required for protection against O(6)-methylguanine triggered apoptosis, DSBs and chromosomal aberrations... DNA Repair (Amst). 2009 Jan 1;8(1):72-86. | |||
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