Drug Information
Drug General Information | Top | |||
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Drug ID |
D08JKW
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Former ID |
DIB019451
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Drug Name |
PMID20409708C34
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Synonyms |
GTPL6321; BDBM50318313
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1], [2] | |
Structure |
Download2D MOL
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Formula |
C21H22N2O3
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Canonical SMILES |
CC(C)(C)C1=CC=C(C=C1)OCC2CN(C(=O)O2)C3=CC=CC(=C3)C#N
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InChI |
1S/C21H22N2O3/c1-21(2,3)16-7-9-18(10-8-16)25-14-19-13-23(20(24)26-19)17-6-4-5-15(11-17)12-22/h4-11,19H,13-14H2,1-3H3/t19-/m0/s1
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InChIKey |
YFJUDGZIRPWFBS-IBGZPJMESA-N
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PubChem Compound ID | ||||
PubChem Substance ID |
Target and Pathway | Top | |||
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Target(s) | Metabotropic glutamate receptor 2 (mGluR2) | Target Info | Modulator (allosteric modulator) | [1] |
KEGG Pathway | Neuroactive ligand-receptor interaction | |||
Glutamatergic synapse | ||||
Cocaine addiction | ||||
Panther Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | ||||
Ionotropic glutamate receptor pathway | ||||
Metabotropic glutamate receptor group II pathway | ||||
Reactome | G alpha (i) signalling events | |||
Class C/3 (Metabotropic glutamate/pheromone receptors) | ||||
WikiPathways | GPCRs, Class C Metabotropic glutamate, pheromone | |||
GPCR ligand binding | ||||
GPCR downstream signaling |
References | Top | |||
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REF 1 | 3-Aryl-5-phenoxymethyl-1,3-oxazolidin-2-ones as positive allosteric modulators of mGluR2 for the treatment of schizophrenia: Hit-to-lead efforts. Bioorg Med Chem Lett. 2010 May 15;20(10):3129-33. | |||
REF 2 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6321). |
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