Drug Information
Drug General Information | Top | |||
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Drug ID |
D08KPK
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Former ID |
DIB020617
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Drug Name |
ONO-AE3-240
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Synonyms |
ONO-AE3240
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL
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Formula |
C34H33N3O3
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Canonical SMILES |
CC(C)CC(C1=CC=CC2=CC=CC=C21)C(=O)NC3=C(C=CC(=C3)CN4C=CC=N4)CC5=CC=CC=C5C(=O)O
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InChI |
1S/C34H33N3O3/c1-23(2)19-31(30-14-7-11-25-9-3-5-12-28(25)30)33(38)36-32-20-24(22-37-18-8-17-35-37)15-16-27(32)21-26-10-4-6-13-29(26)34(39)40/h3-18,20,23,31H,19,21-22H2,1-2H3,(H,36,38)(H,39,40)
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InChIKey |
WXTQSWUTEXDKIF-UHFFFAOYSA-N
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PubChem Compound ID | ||||
PubChem Substance ID |
Target and Pathway | Top | |||
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Target(s) | Prostaglandin E2 receptor EP3 (PTGER3) | Target Info | Antagonist | [2] |
Prostaglandin E2 receptor EP4 (PTGER4) | Target Info | Antagonist | [2] | |
KEGG Pathway | Neuroactive ligand-receptor interaction | |||
Inflammatory mediator regulation of TRP channels | ||||
Renin secretion | ||||
Pathways in cancer | ||||
Calcium signaling pathway | ||||
cAMP signaling pathway | ||||
Regulation of lipolysis in adipocytes | ||||
NetPath Pathway | FSH Signaling Pathway | |||
IL2 Signaling Pathway | ||||
IL4 Signaling Pathway | ||||
TGF_beta_Receptor Signaling Pathway | ||||
Reactome | Prostanoid ligand receptors | |||
G alpha (s) signalling events | ||||
G alpha (i) signalling events | ||||
WikiPathways | Prostaglandin Synthesis and Regulation | |||
GPCRs, Class A Rhodopsin-like | ||||
Vitamin D Receptor Pathway | ||||
Small Ligand GPCRs | ||||
GPCR ligand binding | ||||
GPCR downstream signaling |
References | Top | |||
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REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1943). | |||
REF 2 | Host prostaglandin E(2)-EP3 signaling regulates tumor-associated angiogenesis and tumor growth. J Exp Med. 2003 Jan 20;197(2):221-32. |
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