Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D08SWN
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| Former ID |
DNC014471
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| Drug Name |
(+/-)-threo-3',5'-Dimethylmethylphenidate
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| Synonyms |
CHEMBL1253692; BDBM50327134
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL |
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| Formula |
C16H23NO2
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| Canonical SMILES |
CC1=CC(=CC(=C1)C(C2CCCCN2)C(=O)OC)C
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| InChI |
1S/C16H23NO2/c1-11-8-12(2)10-13(9-11)15(16(18)19-3)14-6-4-5-7-17-14/h8-10,14-15,17H,4-7H2,1-3H3/t14-,15-/m1/s1
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| InChIKey |
OQNVWHLLYQJVEV-HUUCEWRRSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Dopamine transporter (DAT) | Target Info | Inhibitor | [1] |
| KEGG Pathway | Dopaminergic synapse | |||
| Parkinson's disease | ||||
| Cocaine addiction | ||||
| Amphetamine addiction | ||||
| Alcoholism | ||||
| Panther Pathway | Adrenaline and noradrenaline biosynthesis | |||
| Parkinson disease | ||||
| Dopamine receptor mediated signaling pathway | ||||
| Pathway Interaction Database | Alpha-synuclein signaling | |||
| Reactome | Na+/Cl- dependent neurotransmitter transporters | |||
| WikiPathways | Monoamine Transport | |||
| NRF2 pathway | ||||
| Dopaminergic Neurogenesis | ||||
| Parkinsons Disease Pathway | ||||
| Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds | ||||
| Neurotransmitter Clearance In The Synaptic Cleft | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Quantitative structure-activity relationship studies of threo-methylphenidate analogs. Bioorg Med Chem. 2010 Oct 15;18(20):7221-38. | |||
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