Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D08UUK
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| Former ID |
DIB008430
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| Drug Name |
Rostafuroxin
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| Synonyms |
PST-2238; Na+ K+ ATPase (oral, hypertension), Sigma-Tau
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| Drug Type |
Small molecular drug
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| Indication | Hypertension [ICD-11: BA00-BA04; ICD-9: 401] | Phase 2 | [1] | |
| Company |
Sigma-Tau Ind Farm Riunite SpA
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| Structure |
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Download2D MOL |
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| Formula |
C23H34O4
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| Canonical SMILES |
CC12CCC(CC1CCC3C2CCC4(C3(CCC4(C5=COC=C5)O)O)C)O
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| InChI |
1S/C23H34O4/c1-20-8-5-17(24)13-15(20)3-4-19-18(20)6-9-21(2)22(25,10-11-23(19,21)26)16-7-12-27-14-16/h7,12,14-15,17-19,24-26H,3-6,8-11,13H2,1-2H3/t15-,17+,18+,19-,20+,21-,22+,23+/m1/s1
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| InChIKey |
AEAPORIZZWBIEX-DTBDINHYSA-N
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| CAS Number |
CAS 156722-18-8
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| PubChem Compound ID | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT01320397) Antihypertensive Effect of Rostafuroxin Compared With Losartan in Hypertensive Patients Bearing Specified Gene Mutations. U.S. National Institutes of Health. | |||
| REF 2 | Rostafuroxin: an ouabain antagonist that corrects renal and vascular Na+-K+- ATPase alterations in ouabain and adducin-dependent hypertension. Am J Physiol Regul Integr Comp Physiol. 2006 Mar;290(3):R529-35. | |||
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