Drug Information

Drug General Information

Top

Drug ID

D08UZL

Former ID

DNC001452

Drug Name

TMPyP4

Synonyms

TMPP; AC1L1HPJ; N-Methylpyridylylporphyrin; AC1Q29RK; CHEMBL65606; ABCGFHPGHXSVKI-UHFFFAOYSA-O; BDBM50107609; 4,4',4'',4'''-(5,10,15,20-porphyrintetrayl)tetrakis(1-methylpyridinium); J2.096.016G; 5,10,15,20-tetra(1-methyl-4-pyridyl)-porphyrin; 5,10,15,20-tetrakis(1-methylpyridin-1-ium-4-yl)-21,22-dihydroporphyrin

Click to Show/Hide

Drug Type

Small molecular drug

Indication

Multiple myeloma [ICD-11: 2A83; ICD-10: C90.0]

Investigative

[1]

Company

Geron Corp

Structure

Download

2D MOL

Formula

C44H38N8+4

Canonical SMILES

C[N+]1=CC=C(C=C1)C2=C3C=CC(=C(C4=NC(=C(C5=CC=C(N5)C(=C6C=CC2=N6)C7=CC=[N+](C=C7)C)C8=CC=[N+](C=C8)C)C=C4)C9=CC=[N+](C=C9)C)N3

InChI

1S/C44H37N8/c1-49-21-13-29(14-22-49)41-33-5-7-35(45-33)42(30-15-23-50(2)24-16-30)37-9-11-39(47-37)44(32-19-27-52(4)28-20-32)40-12-10-38(48-40)43(36-8-6-34(41)46-36)31-17-25-51(3)26-18-31/h5-28H,1-4H3,(H,45,46,47,48)/q+3/p+1

InChIKey

ABCGFHPGHXSVKI-UHFFFAOYSA-O

CAS Number

CAS 38673-65-3

PubChem Compound ID

135398505

PubChem Substance ID

602793, 866162, 6903208, 7889988, 14888385, 26697455, 26713701, 26715913, 26759637, 29223336, 50064752, 50071044, 57244597, 57322202, 75041861, 85286112, 103134351, 103255147, 104002923, 104305812, 117393983, 134340634, 135021834, 137023655, 137540646, 139738259, 139928079, 140013908, 142721654, 143123259, 143123269, 160855832, 162848634, 163687218, 226613199

Target and Pathway

Top

Target(s)

Telomerase reverse transcriptase (TERT)

Target Info

Inhibitor

[1]

NetPath Pathway

IL2 Signaling Pathway

Pathway Interaction Database

Validated targets of C-MYC transcriptional activation

Regulation of Telomerase