Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D08VTA
|
|||
| Former ID |
DIB004490
|
|||
| Drug Name |
EXP-6803
|
|||
| Synonyms |
114773-44-3; 1H-Imidazole-5-aceticacid, 2-butyl-1-[[4-[(2-carboxybenzoyl)amino]phenyl]methyl]-4-chloro-, 5-methylester, sodium salt (1:1); Exp 6803; AC1Q1VXO; ACMC-20d225; CTK4A8893; sodium 2-(2-butyl-1-{4-[(2-carboxybenzoyl)amino]benzyl}-4-chloro-1h-imidazol-5-yl)propanoate; Methyl 2-n-butyl-1-(4-(2-carboxybenzamido)benzyl)-4-chloroimidazole-5-acetate; 1H-Imidazole-5-acetic acid, 2-butyl-1-((4-((2-carboxybenzoyl)amino)phenyl)methyl)-4-chloro-, alpha-methyl ester, monosodium salt
Click to Show/Hide
|
|||
| Drug Type |
Small molecular drug
|
|||
| Indication | Hypertension [ICD-11: BA00-BA04; ICD-9: 401] | Terminated | [1] | |
| Company |
Bristol-Myers Squibb Pharma Co
|
|||
| Structure |
 |
Download2D MOL |
||
| Formula |
C25H25ClN3NaO5
|
|||
| Canonical SMILES |
CCCCC1=NC(=C(N1CC2=CC=C(C=C2)NC(=O)C3=CC=CC=C3C(=O)O)C(C)C(=O)[O-])Cl.[Na+]
|
|||
| InChI |
1S/C25H26ClN3O5.Na/c1-3-4-9-20-28-22(26)21(15(2)24(31)32)29(20)14-16-10-12-17(13-11-16)27-23(30)18-7-5-6-8-19(18)25(33)34;/h5-8,10-13,15H,3-4,9,14H2,1-2H3,(H,27,30)(H,31,32)(H,33,34);/q;+1/p-1
|
|||
| InChIKey |
OSDQJFVHDVAJSD-UHFFFAOYSA-M
|
|||
| CAS Number |
CAS 114773-44-3
|
|||
| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Angiotensin II receptor (AGTR) | Target Info | Modulator | [2] |
| KEGG Pathway | Calcium signaling pathway | |||
| cGMP-PKG signaling pathway | ||||
| Neuroactive ligand-receptor interaction | ||||
| Adrenergic signaling in cardiomyocytes | ||||
| Vascular smooth muscle contraction | ||||
| Renin-angiotensin system | ||||
| Renin secretion | ||||
| Pathways in cancer | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000418) | |||
| REF 2 | Nonpeptide angiotensin II receptor antagonists. IV. EXP6155 and EXP6803. Hypertension. 1989 May;13(5):489-97. | |||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.