Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D09GDD
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| Former ID |
DNAP001694
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| Drug Name |
Regorafenib
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| Synonyms |
Regorafenib; 755037-03-7; BAY 73-4506; Regorafenibum; Stivarga; 4-(4-(3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy)-N-methylpicolinamide; BAY73-4506; Regorafenib (BAY 73-4506); UNII-24T2A1DOYB; 4-[4-({[4-Chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluorophenoxy]-N-methylpyridine-2-carboxamide; BAY-73-4506; 24T2A1DOYB; CHEMBL1946170; CHEBI:68647; Stivarga (TN); BAY73-4506 hydrochloride; Regorafenib [USAN:INN]
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| Drug Type |
Small molecular drug
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| Indication | Metastatic colorectal cancer [ICD-11: 2B91; ICD-10: C19] | Approved | [1], [2] | |
| Company |
Bayer HealthCare Pharmaceuticals
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| Structure |
 |
Download2D MOL |
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| Formula |
C21H15ClF4N4O3
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| Canonical SMILES |
CNC(=O)C1=NC=CC(=C1)OC2=CC(=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F)F
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| InChI |
1S/C21H15ClF4N4O3/c1-27-19(31)18-10-13(6-7-28-18)33-12-3-5-17(16(23)9-12)30-20(32)29-11-2-4-15(22)14(8-11)21(24,25)26/h2-10H,1H3,(H,27,31)(H2,29,30,32)
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| InChIKey |
FNHKPVJBJVTLMP-UHFFFAOYSA-N
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| CAS Number |
CAS 755037-03-7
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| PubChem Compound ID | ||||
| PubChem Substance ID |
16247148, 23360295, 42222352, 75430857, 99437016, 123055398, 124757057, 124772081, 125163861, 126731249, 131480720, 135261819, 135626856, 135727382, 136367351, 136368060, 136920288, 136937804, 136967459, 137245314, 137275982, 142611634, 144115687, 152090526, 152258021, 152258178, 152344131, 160645781, 160647014, 162011543, 162037486, 163698233, 164041884, 164764796, 172087026, 172093559, 174530361, 175267155, 175427139, 178102514, 186014501, 188899566, 198992717, 223381220, 223498454, 223565986, 223680722, 223704854, 223925935, 226756197
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| ChEBI ID |
CHEBI:68647
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| ADReCS Drug ID | BADD_D01922 | |||
| SuperDrug ATC ID |
L01XE21
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| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5891). | |||
| REF 2 | Nat Rev Drug Discov. 2013 Feb;12(2):87-90. | |||
| REF 3 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
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