Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D09PFR
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| Former ID |
DIB006548
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| Drug Name |
LAMB3-transduced autologous epidermal stem cells
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| Synonyms |
LAMB3-transduced autologous epidermal stem cells (retroviral vector, junctionalepidermolysis bullosa), University of Modena and Reggio Emilia/Holostem; LAMB3-transduced autologous epidermal stem cells (ZFN-mediated transduction, epidermolysis bullosa), University of Modena and Reggio Amilia/San Raffaele-Telethon Institute for Gene Therapy/Sangamo
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| Indication | Epidermolysis bullosa [ICD-11: EC3Z] | Phase 1 | [1] | |
| Company |
University of Modena; Reggio Emilia
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Laminin beta-3 chain (LAMB3) | Target Info | Modulator | [2] |
| KEGG Pathway | PI3K-Akt signaling pathway | |||
| Focal adhesion | ||||
| ECM-receptor interaction | ||||
| Toxoplasmosis | ||||
| Amoebiasis | ||||
| Pathways in cancer | ||||
| Small cell lung cancer | ||||
| Panther Pathway | Integrin signalling pathway | |||
| Pathway Interaction Database | Beta1 integrin cell surface interactions | |||
| Alpha6 beta4 integrin-ligand interactions | ||||
| a6b1 and a6b4 Integrin signaling | ||||
| Reactome | Degradation of the extracellular matrix | |||
| Assembly of collagen fibrils and other multimeric structures | ||||
| Anchoring fibril formation | ||||
| Laminin interactions | ||||
| Non-integrin membrane-ECM interactions | ||||
| WikiPathways | Focal Adhesion | |||
| Assembly of collagen fibrils and other multimeric structures | ||||
| Alpha 6 Beta 4 signaling pathway | ||||
| Integrin cell surface interactions | ||||
| Cell junction organization | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Long-Term Stability and Safety of Transgenic Cultured Epidermal Stem Cells in Gene Therapy of Junctional Epidermolysis Bullosa. Stem Cell Reports. 2014 January 14; 2(1): 1-8. | |||
| REF 2 | Correction of junctional epidermolysis bullosa by transplantation of genetically modified epidermal stem cells. Nat Med. 2006 Dec;12(12):1397-402. | |||
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