Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D09QOR
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| Former ID |
DNCL002735
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| Drug Name |
Eniluracil
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| Synonyms |
Eniluracil; 5-ETHYNYLURACIL; 59989-18-3; 5-ethynylpyrimidine-2,4(1H,3H)-dione; Compound 776C; GW776C85; 5-Ethynylpyrimidine-2,4-diol; 776C85; UNII-2E2W0W5XIU; 5-ethynyl-1H-pyrimidine-2,4-dione; 5-Ethynyl-2,4(1H,3H)-pyrimidinedione; 5-Ethynyl-4-hydroxypyrimidin-2(1H)-one; 5-Ethynyl-6-hydroxypyrimidin-2(1H)-one; 5-Ethynyl-2-hydroxypyrimidin-4(3H)-one; 5-Ethynyl-2-hydroxypyrimidin-4(1H)-one; 5-Ethynyl-2,4(1H,3H)pyrimidinedione; 2E2W0W5XIU; 2,4(1H,3H)-Pyrimidinedione, 5-ethynyl-; CHEMBL355200; C6H4N2O2; Eniluracil [USAN]
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| Drug Type |
Small molecular drug
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| Indication | Hyperlipidaemia [ICD-11: 5C80; ICD-10: E78.5] | Phase 2 | [1] | |
| Company |
Adherex Technologies
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| Structure |
 |
Download2D MOL |
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| Formula |
C6H4N2O2
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| Canonical SMILES |
C#CC1=CNC(=O)NC1=O
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| InChI |
1S/C6H4N2O2/c1-2-4-3-7-6(10)8-5(4)9/h1,3H,(H2,7,8,9,10)
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| InChIKey |
JOZGNYDSEBIJDH-UHFFFAOYSA-N
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| CAS Number |
CAS 59989-18-3
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| PubChem Compound ID | ||||
| PubChem Substance ID |
521438, 7468935, 7840073, 8178018, 12014705, 15170724, 34708593, 47205979, 50064965, 50878122, 57312787, 58107131, 91848806, 103426974, 104016559, 104341532, 126416503, 127319850, 127319851, 127319852, 127319853, 127319854, 127319855, 127319856, 127319857, 128306614, 132522685, 134224378, 135005757, 137030644, 137242733, 140105469, 152187794, 162262065, 163170165, 163410546, 163848391, 164840954, 172913632, 175426856, 179117033, 198972353, 223519221, 223741254, 226423521, 249548404, 250214752, 252075557, 252306248, 252423693
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Dihydrothymine dehydrogenase (DPYD) | Target Info | Modulator | [1] |
| BioCyc | Pyrimidine ribonucleosides degradation | |||
| Thymine degradation | ||||
| Uracil degradation | ||||
| KEGG Pathway | Pyrimidine metabolism | |||
| beta-Alanine metabolism | ||||
| Pantothenate and CoA biosynthesis | ||||
| Drug metabolism - other enzymes | ||||
| Metabolic pathways | ||||
| Panther Pathway | Pyrimidine Metabolism | |||
| Pathwhiz Pathway | Beta-Alanine Metabolism | |||
| Pyrimidine Metabolism | ||||
| WikiPathways | Metabolism of nucleotides | |||
| Fluoropyrimidine Activity | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Eniluracil: an irreversible inhibitor of dihydropyrimidine dehydrogenase. Expert Opin Investig Drugs. 2000 Jul;9(7):1635-49. | |||
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