Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0B1PE
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| Former ID |
DNC001221
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| Drug Name |
Ro 5-4864
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| Synonyms |
4'-Chlorodiazepam; 14439-61-3; 4-Chlorodiazepam; RO5-4864; UNII-2QW0IK1742; HSDB 6958; BRN 0685202; Ro-05-4864; MLS000069627; CHEMBL286346; 2QW0IK1742; Ro-5-4864; SMR000058205; 4 inverted exclamation marka-Chlorodiazepam; 7-Chloro-5-(4-chlorophenyl)-1-methyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one; 7-Chloro-1,3-dihydro-1-methyl-5-(p-chlorophenyl)-2H-1,4-benzodiazepin-2-one; 2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(4-chlorophenyl)-1,3-dihydro-1-methyl-; 7-chloro-5-(4-chlorophenyl)-1-methyl-3H-1,4-benzodiazepin-2-one; NB-3040
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| Drug Type |
Small molecular drug
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| Indication | Gram-positive bacterial infection [ICD-11: 1B74-1G40] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C16H12Cl2N2O
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| Canonical SMILES |
CN1C(=O)CN=C(C2=C1C=CC(=C2)Cl)C3=CC=C(C=C3)Cl
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| InChI |
1S/C16H12Cl2N2O/c1-20-14-7-6-12(18)8-13(14)16(19-9-15(20)21)10-2-4-11(17)5-3-10/h2-8H,9H2,1H3
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| InChIKey |
PUMYFTJOWAJIKF-UHFFFAOYSA-N
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| CAS Number |
CAS 14439-61-3
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| PubChem Compound ID | ||||
| PubChem Substance ID |
629453, 855615, 1064603, 5032806, 8151243, 15396253, 16961256, 24892765, 29220891, 47216957, 47291300, 47365397, 47589165, 47810947, 48035328, 48110640, 49845857, 49884088, 50100939, 56312857, 56422877, 57320986, 74938469, 89651644, 95515627, 103206184, 104298431, 109613651, 124799440, 124883503, 124883504, 128970145, 134223072, 134340266, 134340437, 134349213, 134990592, 137052431, 140280683, 162223583, 166729900, 178126525, 179046571, 198965137, 226442150, 250113435, 252340220
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Polypeptide deformylase (PDF) | Target Info | Inhibitor | [1] |
| Translocator protein (TSPO) | Target Info | Binder | [2], [3] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| HTLV-I infection | ||||
| Pathwhiz Pathway | Folate Metabolism | |||
| Pterine Biosynthesis | ||||
| Reactome | E2F mediated regulation of DNA replication | |||
| Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | ||||
| Metabolism of folate and pterines | ||||
| G1/S-Specific Transcription | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Emerging drugs for bacterial urinary tract infections. Expert Opin Emerg Drugs. 2005 May;10(2):275-98. | |||
| REF 2 | Specific ligands of the peripheral benzodiazepine receptor induce apoptosis and cell cycle arrest in human colorectal cancer cells. Br J Cancer. 2001 Nov 30;85(11):1771-80. | |||
| REF 3 | Antiproliferative and differentiating effects of benzodiazepine receptor ligands on B16 melanoma cells. Biochem Pharmacol. 1998 Oct 15;56(8):1029-34. | |||
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