Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0B2YN
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| Former ID |
DNC013547
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| Drug Name |
1-[(cyclohexylamino)ethyl]-1,1-bisphosphonicacid
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| Synonyms |
CHEMBL261432; [2-(Cyclohexylamino)ethane-1,1-Diyl]bisphosphonic Acid; 2-(cyclohexylamino)ethylidene-1,1-bisphosphonic acid; SCHEMBL9564518; BDBM50374762; 146829-50-7; [2-(cyclohexylamino)-1-phosphono-ethyl]phosphonic acid
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C8H19NO6P2
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| Canonical SMILES |
C1CCC(CC1)NCC(P(=O)(O)O)P(=O)(O)O
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| InChI |
1S/C8H19NO6P2/c10-16(11,12)8(17(13,14)15)6-9-7-4-2-1-3-5-7/h7-9H,1-6H2,(H2,10,11,12)(H2,13,14,15)
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| InChIKey |
OAHUDYBQKIUBMC-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Geranyltranstransferase (FDPS) | Target Info | Inhibitor | [1] |
| BioCyc | Superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate) | |||
| Superpathway of cholesterol biosynthesis | ||||
| Trans, trans-farnesyl diphosphate biosynthesis | ||||
| Geranylgeranyldiphosphate biosynthesis | ||||
| KEGG Pathway | Terpenoid backbone biosynthesis | |||
| Metabolic pathways | ||||
| Biosynthesis of antibiotics | ||||
| NetPath Pathway | TCR Signaling Pathway | |||
| Panther Pathway | Cholesterol biosynthesis | |||
| Pathwhiz Pathway | Steroid Biosynthesis | |||
| Reactome | Cholesterol biosynthesis | |||
| Activation of gene expression by SREBF (SREBP) | ||||
| WikiPathways | Activation of Gene Expression by SREBP (SREBF) | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Synthesis and biological evaluation of 2-alkylaminoethyl-1,1-bisphosphonic acids against Trypanosoma cruzi and Toxoplasma gondii targeting farnesyl... Bioorg Med Chem. 2008 Mar 15;16(6):3283-90. | |||
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